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Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro, In Vivo, and In Silico Investigations of Coumarin-Based Thiazoles.
Hefny SM, El-Moselhy TF, El-Din N, Giovannuzzi S, Bin Traiki T, Vaali-Mohammed MA, El-Dessouki AM, Yamaguchi K, Sugiura M, Shaldam MA, Supuran CT, Abdulla MH, Eldehna WM, Tawfik HO. Hefny SM, et al. Among authors: tawfik ho. J Med Chem. 2024 Apr 20. doi: 10.1021/acs.jmedchem.4c00239. Online ahead of print. J Med Chem. 2024. PMID: 38642371
Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments.
Al-Karmalawy AA, Mousa MHA, Sharaky M, Mourad MAE, El-Dessouki AM, Hamouda AO, Alnajjar R, Ayed AA, Shaldam MA, Tawfik HO. Al-Karmalawy AA, et al. Among authors: tawfik ho. J Med Chem. 2024 Jan 11;67(1):492-512. doi: 10.1021/acs.jmedchem.3c01708. Epub 2023 Dec 20. J Med Chem. 2024. PMID: 38117230
Novel 4-(2-arylidenehydrazineyl)thienopyrimidine derivatives as anticancer EGFR inhibitors: Design, synthesis, biological evaluation, kinome selectivity and in silico insights.
Elsebaie HA, El-Bastawissy EA, Elberembally KM, Khaleel EF, Badi RM, Shaldam MA, Eldehna WM, Tawfik HO, El-Moselhy TF. Elsebaie HA, et al. Among authors: tawfik ho. Bioorg Chem. 2023 Nov;140:106799. doi: 10.1016/j.bioorg.2023.106799. Epub 2023 Aug 22. Bioorg Chem. 2023. PMID: 37625210
32 results