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Page 1
Saccharin Aza Bioisosteres-Synthesis and Preclinical Property Comparisons.
Chen Y, Aurell CJ, Pettersen A, Lewis RJ, Hayes MA, Lepistö M, Jonson AC, Leek H, Thunberg L. Chen Y, et al. Among authors: hayes ma. ACS Med Chem Lett. 2017 May 1;8(6):672-677. doi: 10.1021/acsmedchemlett.7b00137. eCollection 2017 Jun 8. ACS Med Chem Lett. 2017. PMID: 28626531 Free PMC article.
Discovery of (3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone (AZD1979), a Melanin Concentrating Hormone Receptor 1 (MCHr1) Antagonist with Favorable Physicochemical Properties.
Johansson A, Löfberg C, Antonsson M, von Unge S, Hayes MA, Judkins R, Ploj K, Benthem L, Lindén D, Brodin P, Wennerberg M, Fredenwall M, Li L, Persson J, Bergman R, Pettersen A, Gennemark P, Hogner A. Johansson A, et al. Among authors: hayes ma. J Med Chem. 2016 Mar 24;59(6):2497-511. doi: 10.1021/acs.jmedchem.5b01654. Epub 2016 Feb 5. J Med Chem. 2016. PMID: 26741166
Biocatalysis in Drug Design: Engineered Reductive Aminases (RedAms) Are Used to Access Chiral Building Blocks with Multiple Stereocenters.
Casamajo AR, Yu Y, Schnepel C, Morrill C, Barker R, Levy CW, Finnigan J, Spelling V, Westerlund K, Petchey M, Sheppard RJ, Lewis RJ, Falcioni F, Hayes MA, Turner NJ. Casamajo AR, et al. Among authors: hayes ma. J Am Chem Soc. 2023 Oct 11;145(40):22041-22046. doi: 10.1021/jacs.3c07010. Epub 2023 Oct 2. J Am Chem Soc. 2023. PMID: 37782882 Free PMC article.
Exploring the enzyme-catalyzed synthesis of isotope labeled cyclopropanes.
Sardana M, Mühlfenzl KS, Wenker STM, Åkesson C, Hayes MA, Elmore CS, Pithani S. Sardana M, et al. Among authors: hayes ma. J Labelled Comp Radiopharm. 2022 Apr;65(4):86-100. doi: 10.1002/jlcr.3962. Epub 2022 Feb 2. J Labelled Comp Radiopharm. 2022. PMID: 34997781 Free PMC article.
Oxetane Substrates of Human Microsomal Epoxide Hydrolase.
Toselli F, Fredenwall M, Svensson P, Li XQ, Johansson A, Weidolf L, Hayes MA. Toselli F, et al. Among authors: hayes ma. Drug Metab Dispos. 2017 Aug;45(8):966-973. doi: 10.1124/dmd.117.076489. Epub 2017 Jun 9. Drug Metab Dispos. 2017. PMID: 28600384
342 results