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Mitochondrial dysfunction underlying sporadic inclusion body myositis is ameliorated by the mitochondrial homing drug MA-5.
Oikawa Y, Izumi R, Koide M, Hagiwara Y, Kanzaki M, Suzuki N, Kikuchi K, Matsuhashi T, Akiyama Y, Ichijo M, Watanabe S, Toyohara T, Suzuki T, Mishima E, Akiyama Y, Ogata Y, Suzuki C, Hayashi H, Kodama EN, Hayashi KI, Itoi E, Aoki M, Kure S, Abe T. Oikawa Y, et al. Among authors: hayashi h, hayashi ki. PLoS One. 2020 Dec 2;15(12):e0231064. doi: 10.1371/journal.pone.0231064. eCollection 2020. PLoS One. 2020. PMID: 33264289 Free PMC article.
A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication.
Hattori SI, Higashi-Kuwata N, Hayashi H, Allu SR, Raghavaiah J, Bulut H, Das D, Anson BJ, Lendy EK, Takamatsu Y, Takamune N, Kishimoto N, Murayama K, Hasegawa K, Li M, Davis DA, Kodama EN, Yarchoan R, Wlodawer A, Misumi S, Mesecar AD, Ghosh AK, Mitsuya H. Hattori SI, et al. Among authors: hayashi h. Nat Commun. 2021 Jan 28;12(1):668. doi: 10.1038/s41467-021-20900-6. Nat Commun. 2021. PMID: 33510133 Free PMC article.
Disseminated tuberculosis with paradoxical reactions caused by a Mycobacterium tuberculosis strain belonging to the Indo-Oceanic lineage: An imported case in Japan.
Oshima K, Nakajima C, Hirata K, Hayashi H, Kodama EN, Fukushima Y, Suzuki Y, Kanamori H, Baba H, Aoyagi T, Tokuda K, Kaku M. Oshima K, et al. Among authors: hayashi h. J Infect Chemother. 2022 Jul;28(7):965-970. doi: 10.1016/j.jiac.2022.02.008. Epub 2022 Mar 4. J Infect Chemother. 2022. PMID: 35249818
Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors.
Makino Y, Oe C, Iwama K, Suzuki S, Nishiyama A, Hasegawa K, Okuda H, Hirata K, Ueno M, Kawaji K, Sasano M, Usui E, Hosaka T, Yabuki Y, Shirouzu M, Katsumi M, Murayama K, Hayashi H, Kodama EN. Makino Y, et al. Among authors: hayashi h. Commun Biol. 2022 Jun 23;5(1):619. doi: 10.1038/s42003-022-03555-x. Commun Biol. 2022. PMID: 35739195 Free PMC article.
Helix-based screening with structure prediction using artificial intelligence has potential for the rapid development of peptide inhibitors targeting class I viral fusion.
Suzuki S, Kuroda M, Aoki K, Kawaji K, Hiramatsu Y, Sasano M, Nishiyama A, Murayama K, Kodama EN, Oishi S, Hayashi H. Suzuki S, et al. Among authors: hayashi h. RSC Chem Biol. 2023 Nov 7;5(2):131-140. doi: 10.1039/d3cb00166k. eCollection 2024 Feb 7. RSC Chem Biol. 2023. PMID: 38333196 Free PMC article.
6,416 results