Hawley SA - Search Results

1

Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling.

Rutherford C, Speirs C, Williams JJ, Ewart MA, Mancini SJ, Hawley SA, Delles C, Viollet B, Costa-Pereira AP, Baillie GS, Salt IP, Palmer TM. Rutherford C, et al. Among authors: hawley sa. Sci Signal. 2016 Nov 8;9(453):ra109. doi: 10.1126/scisignal.aaf8566. Sci Signal. 2016. PMID: 27919027 Free article.

2

The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels.

Hawley SA, Ford RJ, Smith BK, Gowans GJ, Mancini SJ, Pitt RD, Day EA, Salt IP, Steinberg GR, Hardie DG. Hawley SA, et al. Diabetes. 2016 Sep;65(9):2784-94. doi: 10.2337/db16-0058. Epub 2016 Jul 5. Diabetes. 2016. PMID: 27381369 Free PMC article.

3

AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge.

Hardie DG, Salt IP, Hawley SA, Davies SP. Hardie DG, et al. Among authors: hawley sa. Biochem J. 1999 Mar 15;338 ( Pt 3)(Pt 3):717-22. Biochem J. 1999. PMID: 10051444 Free PMC article.

4

AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform.

Salt I, Celler JW, Hawley SA, Prescott A, Woods A, Carling D, Hardie DG. Salt I, et al. Among authors: hawley sa. Biochem J. 1998 Aug 15;334 ( Pt 1)(Pt 1):177-87. doi: 10.1042/bj3340177. Biochem J. 1998. PMID: 9693118 Free PMC article.

5

Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK.

Hunter RW, Foretz M, Bultot L, Fullerton MD, Deak M, Ross FA, Hawley SA, Shpiro N, Viollet B, Barron D, Kemp BE, Steinberg GR, Hardie DG, Sakamoto K. Hunter RW, et al. Among authors: hawley sa. Chem Biol. 2014 Jul 17;21(7):866-79. doi: 10.1016/j.chembiol.2014.05.014. Chem Biol. 2014. PMID: 25036776 Free PMC article.

6

Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

Göransson O, McBride A, Hawley SA, Ross FA, Shpiro N, Foretz M, Viollet B, Hardie DG, Sakamoto K. Göransson O, et al. Among authors: hawley sa. J Biol Chem. 2007 Nov 9;282(45):32549-60. doi: 10.1074/jbc.M706536200. Epub 2007 Sep 12. J Biol Chem. 2007. PMID: 17855357 Free PMC article.

7

The ancient drug salicylate directly activates AMP-activated protein kinase.

Hawley SA, Fullerton MD, Ross FA, Schertzer JD, Chevtzoff C, Walker KJ, Peggie MW, Zibrova D, Green KA, Mustard KJ, Kemp BE, Sakamoto K, Steinberg GR, Hardie DG. Hawley SA, et al. Science. 2012 May 18;336(6083):918-22. doi: 10.1126/science.1215327. Epub 2012 Apr 19. Science. 2012. PMID: 22517326 Free PMC article.

8

Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP.

Fogarty S, Hawley SA, Green KA, Saner N, Mustard KJ, Hardie DG. Fogarty S, et al. Among authors: hawley sa. Biochem J. 2010 Jan 27;426(1):109-18. doi: 10.1042/BJ20091372. Biochem J. 2010. PMID: 19958286 Free PMC article.

9

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells.

Hawley SA, Ross FA, Gowans GJ, Tibarewal P, Leslie NR, Hardie DG. Hawley SA, et al. Biochem J. 2014 Apr 15;459(2):275-87. doi: 10.1042/BJ20131344. Biochem J. 2014. PMID: 24467442 Free PMC article.

10

AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation.

Gowans GJ, Hawley SA, Ross FA, Hardie DG. Gowans GJ, et al. Among authors: hawley sa. Cell Metab. 2013 Oct 1;18(4):556-66. doi: 10.1016/j.cmet.2013.08.019. Cell Metab. 2013. PMID: 24093679 Free PMC article.

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