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GLP-1R signaling neighborhoods associate with the susceptibility to adverse drug reactions of incretin mimetics.
Wright SC, Motso A, Koutsilieri S, Beusch CM, Sabatier P, Berghella A, Blondel-Tepaz É, Mangenot K, Pittarokoilis I, Sismanoglou DC, Le Gouill C, Olsen JV, Zubarev RA, Lambert NA, Hauser AS, Bouvier M, Lauschke VM. Wright SC, et al. Among authors: hauser as. Nat Commun. 2023 Oct 9;14(1):6243. doi: 10.1038/s41467-023-41893-4. Nat Commun. 2023. PMID: 37813859 Free PMC article.
GPCR activation mechanisms across classes and macro/microscales.
Hauser AS, Kooistra AJ, Munk C, Heydenreich FM, Veprintsev DB, Bouvier M, Babu MM, Gloriam DE. Hauser AS, et al. Nat Struct Mol Biol. 2021 Nov;28(11):879-888. doi: 10.1038/s41594-021-00674-7. Epub 2021 Nov 10. Nat Struct Mol Biol. 2021. PMID: 34759375 Free PMC article.
Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs.
Avet C, Mancini A, Breton B, Le Gouill C, Hauser AS, Normand C, Kobayashi H, Gross F, Hogue M, Lukasheva V, St-Onge S, Carrier M, Héroux M, Morissette S, Fauman EB, Fortin JP, Schann S, Leroy X, Gloriam DE, Bouvier M. Avet C, et al. Among authors: hauser as. Elife. 2022 Mar 18;11:e74101. doi: 10.7554/eLife.74101. Elife. 2022. PMID: 35302493 Free PMC article.
Common coupling map advances GPCR-G protein selectivity.
Hauser AS, Avet C, Normand C, Mancini A, Inoue A, Bouvier M, Gloriam DE. Hauser AS, et al. Elife. 2022 Mar 18;11:e74107. doi: 10.7554/eLife.74107. Elife. 2022. PMID: 35302494 Free PMC article.
A community Biased Signaling Atlas.
Caroli J, Mamyrbekov A, Harpsøe K, Gardizi S, Dörries L, Ghosh E, Hauser AS, Kooistra AJ, Gloriam DE. Caroli J, et al. Among authors: hauser as. Nat Chem Biol. 2023 May;19(5):531-535. doi: 10.1038/s41589-023-01292-8. Nat Chem Biol. 2023. PMID: 36973443 No abstract available.
Selectivity determinants of GPCR-G-protein binding.
Flock T, Hauser AS, Lund N, Gloriam DE, Balaji S, Babu MM. Flock T, et al. Among authors: hauser as. Nature. 2017 May 18;545(7654):317-322. doi: 10.1038/nature22070. Epub 2017 May 10. Nature. 2017. PMID: 28489817 Free PMC article.
Trends in GPCR drug discovery: new agents, targets and indications.
Hauser AS, Attwood MM, Rask-Andersen M, Schiöth HB, Gloriam DE. Hauser AS, et al. Nat Rev Drug Discov. 2017 Dec;16(12):829-842. doi: 10.1038/nrd.2017.178. Epub 2017 Oct 27. Nat Rev Drug Discov. 2017. PMID: 29075003 Free PMC article. Review.
Mutational Landscape of the Proglucagon-Derived Peptides.
Lindquist P, Madsen JS, Bräuner-Osborne H, Rosenkilde MM, Hauser AS. Lindquist P, et al. Among authors: hauser as. Front Endocrinol (Lausanne). 2021 Jun 17;12:698511. doi: 10.3389/fendo.2021.698511. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34220721 Free PMC article.
35 results