Hatton D - Search Results

1

Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins.

Malm M, Kuo CC, Barzadd MM, Mebrahtu A, Wistbacka N, Razavi R, Volk AL, Lundqvist M, Kotol D, Tegel H, Hober S, Edfors F, Gräslund T, Chotteau V, Field R, Varley PG, Roth RG, Lewis NE, Hatton D, Rockberg J. Malm M, et al. Among authors: hatton d. Metab Eng. 2022 Jul;72:171-187. doi: 10.1016/j.ymben.2022.03.009. Epub 2022 Mar 14. Metab Eng. 2022. PMID: 35301123 Free PMC article.

2

Determination of Chinese hamster ovary cell line stability and recombinant antibody expression during long-term culture.

Bailey LA, Hatton D, Field R, Dickson AJ. Bailey LA, et al. Among authors: hatton d. Biotechnol Bioeng. 2012 Aug;109(8):2093-103. doi: 10.1002/bit.24485. Biotechnol Bioeng. 2012. PMID: 22896849

3

A high-yielding CHO transient system: coexpression of genes encoding EBNA-1 and GS enhances transient protein expression.

Daramola O, Stevenson J, Dean G, Hatton D, Pettman G, Holmes W, Field R. Daramola O, et al. Among authors: hatton d. Biotechnol Prog. 2014 Jan-Feb;30(1):132-41. doi: 10.1002/btpr.1809. Epub 2013 Oct 10. Biotechnol Prog. 2014. PMID: 24106171

4

Polysome profiling of mAb producing CHO cell lines links translational control of cell proliferation and recombinant mRNA loading onto ribosomes with global and recombinant protein synthesis.

Godfrey CL, Mead EJ, Daramola O, Dunn S, Hatton D, Field R, Pettman G, Smales CM. Godfrey CL, et al. Among authors: hatton d. Biotechnol J. 2017 Aug;12(8). doi: 10.1002/biot.201700177. Epub 2017 Jul 5. Biotechnol J. 2017. PMID: 28504349

5

Whole synthetic pathway engineering of recombinant protein production.

Brown AJ, Gibson SJ, Hatton D, Arnall CL, James DC. Brown AJ, et al. Among authors: hatton d. Biotechnol Bioeng. 2019 Feb;116(2):375-387. doi: 10.1002/bit.26855. Epub 2018 Nov 5. Biotechnol Bioeng. 2019. PMID: 30345502 Free article.

6

A platform for context-specific genetic engineering of recombinant protein production by CHO cells.

Cartwright JF, Arnall CL, Patel YD, Barber NOW, Lovelady CS, Rosignoli G, Harris CL, Dunn S, Field RP, Dean G, Daramola O, Gibson SJ, Peden AA, Brown AJ, Hatton D, James DC. Cartwright JF, et al. Among authors: hatton d. J Biotechnol. 2020 Mar 20;312:11-22. doi: 10.1016/j.jbiotec.2020.02.012. Epub 2020 Feb 27. J Biotechnol. 2020. PMID: 32114154

7

Systematic use of synthetic 5'-UTR RNA structures to tune protein translation improves yield and quality of complex proteins in mammalian cell factories.

Eisenhut P, Mebrahtu A, Moradi Barzadd M, Thalén N, Klanert G, Weinguny M, Sandegren A, Su C, Hatton D, Borth N, Rockberg J. Eisenhut P, et al. Among authors: hatton d. Nucleic Acids Res. 2020 Nov 18;48(20):e119. doi: 10.1093/nar/gkaa847. Nucleic Acids Res. 2020. PMID: 33051690 Free PMC article.

8

Low Shear Stress Increases Recombinant Protein Production and High Shear Stress Increases Apoptosis in Human Cells.

Zhan C, Bidkhori G, Schwarz H, Malm M, Mebrahtu A, Field R, Sellick C, Hatton D, Varley P, Mardinoglu A, Rockberg J, Chotteau V. Zhan C, et al. Among authors: hatton d. iScience. 2020 Oct 7;23(11):101653. doi: 10.1016/j.isci.2020.101653. eCollection 2020 Nov 20. iScience. 2020. PMID: 33145483 Free PMC article.

9

Evolution from adherent to suspension: systems biology of HEK293 cell line development.

Malm M, Saghaleyni R, Lundqvist M, Giudici M, Chotteau V, Field R, Varley PG, Hatton D, Grassi L, Svensson T, Nielsen J, Rockberg J. Malm M, et al. Among authors: hatton d. Sci Rep. 2020 Nov 4;10(1):18996. doi: 10.1038/s41598-020-76137-8. Sci Rep. 2020. PMID: 33149219 Free PMC article.

10

Author Correction: Evolution from adherent to suspension: systems biology of HEK293 cell line development.

Malm M, Saghaleyni R, Lundqvist M, Giudici M, Chotteau V, Field R, Varley PG, Hatton D, Grassi L, Svensson T, Nielsen J, Rockberg J. Malm M, et al. Among authors: hatton d. Sci Rep. 2021 Mar 2;11(1):5407. doi: 10.1038/s41598-021-85105-9. Sci Rep. 2021. PMID: 33654173 Free PMC article. No abstract available.

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