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Suspected limited efficacy of γ-secretase modulators.
Kakuda N, Akazawa K, Hatsuta H, Murayama S, Ihara Y; Japanese Alzheimer's Disease Neuroimaging Initiative. Kakuda N, et al. Among authors: hatsuta h. Neurobiol Aging. 2013 Apr;34(4):1101-4. doi: 10.1016/j.neurobiolaging.2012.08.017. Epub 2012 Oct 9. Neurobiol Aging. 2013. PMID: 23058852
Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease.
Kakuda N, Shoji M, Arai H, Furukawa K, Ikeuchi T, Akazawa K, Takami M, Hatsuta H, Murayama S, Hashimoto Y, Miyajima M, Arai H, Nagashima Y, Yamaguchi H, Kuwano R, Nagaike K, Ihara Y; Japanese Alzheimer's Disease Neuroimaging Initiative. Kakuda N, et al. Among authors: hatsuta h. EMBO Mol Med. 2012 Apr;4(4):344-52. doi: 10.1002/emmm.201200214. Epub 2012 Feb 21. EMBO Mol Med. 2012. PMID: 22354516 Free PMC article.
γ-Secretase Activity Is Associated with Braak Senile Plaque Stages.
Kakuda N, Yamaguchi H, Akazawa K, Hata S, Suzuki T, Hatsuta H, Murayama S, Funamoto S, Ihara Y. Kakuda N, et al. Among authors: hatsuta h. Am J Pathol. 2020 Jun;190(6):1323-1331. doi: 10.1016/j.ajpath.2020.02.009. Epub 2020 Mar 20. Am J Pathol. 2020. PMID: 32201261 Free article.
Genes associated with the progression of neurofibrillary tangles in Alzheimer's disease.
Miyashita A, Hatsuta H, Kikuchi M, Nakaya A, Saito Y, Tsukie T, Hara N, Ogishima S, Kitamura N, Akazawa K, Kakita A, Takahashi H, Murayama S, Ihara Y, Ikeuchi T, Kuwano R; Japanese Alzheimer's Disease Neuroimaging Initiative. Miyashita A, et al. Among authors: hatsuta h. Transl Psychiatry. 2014 Jun 10;4(6):e396. doi: 10.1038/tp.2014.35. Transl Psychiatry. 2014. PMID: 26126179 Free PMC article.
The homologous carboxyl-terminal domains of microtubule-associated protein 2 and TAU induce neuronal dysfunction and have differential fates in the evolution of neurofibrillary tangles.
Xie C, Miyasaka T, Yoshimura S, Hatsuta H, Yoshina S, Kage-Nakadai E, Mitani S, Murayama S, Ihara Y. Xie C, et al. Among authors: hatsuta h. PLoS One. 2014 Feb 25;9(2):e89796. doi: 10.1371/journal.pone.0089796. eCollection 2014. PLoS One. 2014. PMID: 24587039 Free PMC article.
Lack of genetic association between TREM2 and late-onset Alzheimer's disease in a Japanese population.
Miyashita A, Wen Y, Kitamura N, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Furukawa K, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Nishizawa M, Suga M, Kawase Y, Akatsu H, Imagawa M, Hamaguchi T, Yamada M, Morihara T, Takeda M, Takao T, Nakata K, Sasaki K, Watanabe K, Nakashima K, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa K, Yoshimoto S, Nakagawa R, Saito Y, Hatsuta H, Murayama S, Kakita A, Takahashi H, Yamaguchi H, Akazawa K, Kanazawa I, Ihara Y, Ikeuchi T, Kuwano R. Miyashita A, et al. Among authors: hatsuta h. J Alzheimers Dis. 2014;41(4):1031-8. doi: 10.3233/JAD-140225. J Alzheimers Dis. 2014. PMID: 24762945
Immunostaining of oxidized DJ-1 in human and mouse brains.
Saito Y, Miyasaka T, Hatsuta H, Takahashi-Niki K, Hayashi K, Mita Y, Kusano-Arai O, Iwanari H, Ariga H, Hamakubo T, Yoshida Y, Niki E, Murayama S, Ihara Y, Noguchi N. Saito Y, et al. Among authors: hatsuta h. J Neuropathol Exp Neurol. 2014 Jul;73(7):714-28. doi: 10.1097/NEN.0000000000000087. J Neuropathol Exp Neurol. 2014. PMID: 24918637 Free PMC article.
Excess APP O-glycosylation by GalNAc-T6 decreases Aβ production.
Akasaka-Manya K, Kawamura M, Tsumoto H, Saito Y, Tachida Y, Kitazume S, Hatsuta H, Miura Y, Hisanaga SI, Murayama S, Hashimoto Y, Manya H, Endo T. Akasaka-Manya K, et al. Among authors: hatsuta h. J Biochem. 2017 Jan;161(1):99-111. doi: 10.1093/jb/mvw056. Epub 2016 Oct 19. J Biochem. 2017. PMID: 28053144
53 results