Hatley O - Search Results

1

Development of a Korean-specific virtual population for physiologically based pharmacokinetic modelling and simulation.

Kim Y, Hatley O, Rhee SJ, Yi S, Lee HA, Yoon S, Chung JY, Yu KS, Lee H. Kim Y, et al. Among authors: hatley o. Biopharm Drug Dispos. 2019 Apr;40(3-4):135-150. doi: 10.1002/bdd.2178. Biopharm Drug Dispos. 2019. PMID: 30921829

2

Optimization of intestinal microsomal preparation in the rat: A systematic approach to assess the influence of various methodologies on metabolic activity and scaling factors.

Hatley OJD, Jones CR, Galetin A, Rostami-Hodjegan A. Hatley OJD, et al. Biopharm Drug Dispos. 2017 Apr;38(3):187-208. doi: 10.1002/bdd.2070. Biopharm Drug Dispos. 2017. PMID: 28207929 Free PMC article.

3

Simulating the Impact of Elevated Levels of Interleukin-6 on the Pharmacokinetics of Various CYP450 Substrates in Patients with Neuromyelitis Optica or Neuromyelitis Optica Spectrum Disorders in Different Ethnic Populations.

Machavaram KK, Endo-Tsukude C, Terao K, Gill KL, Hatley OJ, Gardner I, Parrott N, Ducray PS. Machavaram KK, et al. AAPS J. 2019 Mar 18;21(3):42. doi: 10.1208/s12248-019-0309-y. AAPS J. 2019. PMID: 30887238

4

A physiologically based pharmacokinetic - pharmacodynamic modelling approach to predict incidence of neutropenia as a result of drug-drug interactions of paclitaxel in cancer patients.

Mendes MS, Hatley O, Gill KL, Yeo KR, Ke AB. Mendes MS, et al. Among authors: hatley o. Eur J Pharm Sci. 2020 Jul 1;150:105355. doi: 10.1016/j.ejps.2020.105355. Epub 2020 May 18. Eur J Pharm Sci. 2020. PMID: 32438273

5

Development of a physiologically based pharmacokinetic (PBPK) population model for Chinese elderly subjects.

Cui C, Valerie Sia JE, Tu S, Li X, Dong Z, Yu Z, Yao X, Hatley O, Li H, Liu D. Cui C, et al. Among authors: hatley o. Br J Clin Pharmacol. 2021 Jul;87(7):2711-2722. doi: 10.1111/bcp.14609. Epub 2021 May 18. Br J Clin Pharmacol. 2021. PMID: 33068053 Free PMC article.

6

Prediction of CYP-mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator.

Kilford PJ, Chen KF, Crewe K, Gardner I, Hatley O, Ke AB, Neuhoff S, Zhang M, Rowland Yeo K. Kilford PJ, et al. Among authors: hatley o. CPT Pharmacometrics Syst Pharmacol. 2022 Jul;11(7):822-832. doi: 10.1002/psp4.12794. Epub 2022 Apr 28. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 35445542 Free PMC article.

7

Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model.

Almond LM, Mukadam S, Gardner I, Okialda K, Wong S, Hatley O, Tay S, Rowland-Yeo K, Jamei M, Rostami-Hodjegan A, Kenny JR. Almond LM, et al. Among authors: hatley o. Drug Metab Dispos. 2016 Jun;44(6):821-32. doi: 10.1124/dmd.115.066845. Epub 2016 Mar 29. Drug Metab Dispos. 2016. PMID: 27026679 Free PMC article.

8

Quantifying gut wall metabolism: methodology matters.

Hatley OJ, Jones CR, Galetin A, Rostami-Hodjegan A. Hatley OJ, et al. Biopharm Drug Dispos. 2017 Mar;38(2):155-160. doi: 10.1002/bdd.2062. Epub 2017 Feb 14. Biopharm Drug Dispos. 2017. PMID: 28039878 Free PMC article. No abstract available.

9

Pretreatment With Rifampicin and Tyrosine Kinase Inhibitor Dasatinib Potentiates the Inhibitory Effects Toward OATP1B1- and OATP1B3-Mediated Transport.

Pahwa S, Alam K, Crowe A, Farasyn T, Neuhoff S, Hatley O, Ding K, Yue W. Pahwa S, et al. Among authors: hatley o. J Pharm Sci. 2017 Aug;106(8):2123-2135. doi: 10.1016/j.xphs.2017.03.022. Epub 2017 Apr 1. J Pharm Sci. 2017. PMID: 28373111 Free PMC article.

10

Assessing OATP1B1- and OATP1B3-Mediated Drug-Drug Interaction Potential of Vemurafenib Using R-Value and Physiologically-Based Pharmacokinetic Models.

Kayesh R, Farasyn T, Crowe A, Liu Q, Pahwa S, Alam K, Neuhoff S, Hatley O, Ding K, Yue W. Kayesh R, et al. Among authors: hatley o. J Pharm Sci. 2021 Jan;110(1):314-324. doi: 10.1016/j.xphs.2020.06.016. Epub 2020 Jun 23. J Pharm Sci. 2021. PMID: 32590030 Free PMC article.

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