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A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells.
Kawano S, Maruyama J, Nagashima S, Inami K, Qiu W, Iwasa H, Nakagawa K, Ishigami-Yuasa M, Kagechika H, Nishina H, Hata Y. Kawano S, et al. Among authors: hata y. J Biochem. 2015 Nov;158(5):413-23. doi: 10.1093/jb/mvv051. Epub 2015 May 14. J Biochem. 2015. PMID: 25979969
Validation of chemical compound library screening for transcriptional co-activator with PDZ-binding motif inhibitors using GFP-fused transcriptional co-activator with PDZ-binding motif.
Nagashima S, Maruyama J, Kawano S, Iwasa H, Nakagawa K, Ishigami-Yuasa M, Kagechika H, Nishina H, Hata Y. Nagashima S, et al. Among authors: hata y. Cancer Sci. 2016 Jun;107(6):791-802. doi: 10.1111/cas.12936. Epub 2016 May 12. Cancer Sci. 2016. PMID: 27009852 Free PMC article.
Characterization of a novel compound that promotes myogenesis via Akt and transcriptional co-activator with PDZ-binding motif (TAZ) in mouse C2C12 cells.
Kodaka M, Mao F, Arimoto-Matsuzaki K, Kitamura M, Xu X, Yang Z, Nakagawa K, Maruyama J, Ishii K, Akazawa C, Oyaizu T, Yamamoto N, Ishigami-Yuasa M, Tsuemoto N, Ito S, Kagechika H, Nishina H, Hata Y. Kodaka M, et al. Among authors: hata y. PLoS One. 2020 Apr 8;15(4):e0231265. doi: 10.1371/journal.pone.0231265. eCollection 2020. PLoS One. 2020. PMID: 32267872 Free PMC article.
Screening with a novel cell-based assay for TAZ activators identifies a compound that enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model.
Yang Z, Nakagawa K, Sarkar A, Maruyama J, Iwasa H, Bao Y, Ishigami-Yuasa M, Ito S, Kagechika H, Hata S, Nishina H, Abe S, Kitagawa M, Hata Y. Yang Z, et al. Among authors: hata y, hata s. Mol Cell Biol. 2014 May;34(9):1607-21. doi: 10.1128/MCB.01346-13. Epub 2014 Feb 18. Mol Cell Biol. 2014. PMID: 24550007 Free PMC article.
A new cell-based assay to evaluate myogenesis in mouse myoblast C2C12 cells.
Kodaka M, Yang Z, Nakagawa K, Maruyama J, Xu X, Sarkar A, Ichimura A, Nasu Y, Ozawa T, Iwasa H, Ishigami-Yuasa M, Ito S, Kagechika H, Hata Y. Kodaka M, et al. Among authors: hata y. Exp Cell Res. 2015 Aug 15;336(2):171-81. doi: 10.1016/j.yexcr.2015.06.015. Epub 2015 Jun 24. Exp Cell Res. 2015. PMID: 26116467
1,465 results