Hashimoto T - Search Results

1

Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer's disease.

Kaneshiro N, Komai M, Imaoka R, Ikeda A, Kamikubo Y, Saito T, Saido TC, Tomita T, Hashimoto T, Iwatsubo T, Sakurai T, Uehara T, Takasugi N. Kaneshiro N, et al. Among authors: hashimoto t. iScience. 2022 Feb 4;25(3):103869. doi: 10.1016/j.isci.2022.103869. eCollection 2022 Mar 18. iScience. 2022. PMID: 35243232 Free PMC article.

2

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

Tomita T, Tokuhiro S, Hashimoto T, Aiba K, Saido TC, Maruyama K, Iwatsubo T. Tomita T, et al. Among authors: hashimoto t. J Biol Chem. 1998 Aug 14;273(33):21153-60. doi: 10.1074/jbc.273.33.21153. J Biol Chem. 1998. PMID: 9694871 Free article.

3

CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV.

Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DM, Iwatsubo T. Hashimoto T, et al. EMBO J. 2002 Apr 2;21(7):1524-34. doi: 10.1093/emboj/21.7.1524. EMBO J. 2002. PMID: 11927537 Free PMC article.

4

Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease.

Wakutani Y, Watanabe K, Adachi Y, Wada-Isoe K, Urakami K, Ninomiya H, Saido TC, Hashimoto T, Iwatsubo T, Nakashima K. Wakutani Y, et al. Among authors: hashimoto t. J Neurol Neurosurg Psychiatry. 2004 Jul;75(7):1039-42. doi: 10.1136/jnnp.2003.010611. J Neurol Neurosurg Psychiatry. 2004. PMID: 15201367 Free PMC article.

5

Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits.

Kowa H, Sakakura T, Matsuura Y, Wakabayashi T, Mann DM, Duff K, Tsuji S, Hashimoto T, Iwatsubo T. Kowa H, et al. Among authors: hashimoto t. Am J Pathol. 2004 Jul;165(1):273-81. doi: 10.1016/s0002-9440(10)63295-6. Am J Pathol. 2004. PMID: 15215182 Free PMC article.

6

CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils.

Osada Y, Hashimoto T, Nishimura A, Matsuo Y, Wakabayashi T, Iwatsubo T. Osada Y, et al. Among authors: hashimoto t. J Biol Chem. 2005 Mar 4;280(9):8596-605. doi: 10.1074/jbc.M413340200. Epub 2004 Dec 21. J Biol Chem. 2005. PMID: 15615705 Free article.

7

Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver.

Tamaki C, Ohtsuki S, Iwatsubo T, Hashimoto T, Yamada K, Yabuki C, Terasaki T. Tamaki C, et al. Among authors: hashimoto t. Pharm Res. 2006 Jul;23(7):1407-16. doi: 10.1007/s11095-006-0208-7. Epub 2006 Jun 21. Pharm Res. 2006. PMID: 16779710

8

The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Abeta fibril formation without increasing protofibril formation.

Hori Y, Hashimoto T, Wakutani Y, Urakami K, Nakashima K, Condron MM, Tsubuki S, Saido TC, Teplow DB, Iwatsubo T. Hori Y, et al. Among authors: hashimoto t. J Biol Chem. 2007 Feb 16;282(7):4916-4923. doi: 10.1074/jbc.M608220200. Epub 2006 Dec 14. J Biol Chem. 2007. PMID: 17170111 Free article.

9

Analytical method for beta-amyloid fibrils using CE-laser induced fluorescence and its application to screening for inhibitors of beta-amyloid protein aggregation.

Kato M, Kinoshita H, Enokita M, Hori Y, Hashimoto T, Iwatsubo T, Toyo'oka T. Kato M, et al. Among authors: hashimoto t. Anal Chem. 2007 Jul 1;79(13):4887-91. doi: 10.1021/ac0701482. Epub 2007 May 31. Anal Chem. 2007. PMID: 17536782

10

The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells.

Yamada K, Hashimoto T, Yabuki C, Nagae Y, Tachikawa M, Strickland DK, Liu Q, Bu G, Basak JM, Holtzman DM, Ohtsuki S, Terasaki T, Iwatsubo T. Yamada K, et al. Among authors: hashimoto t. J Biol Chem. 2008 Dec 12;283(50):34554-62. doi: 10.1074/jbc.M801487200. Epub 2008 Oct 21. J Biol Chem. 2008. PMID: 18940800 Free PMC article.

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