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BMP-2 (and partially GDF-5) coating significantly accelerates and augments bone formation close to hydroxyapatite/tricalcium-phosphate/brushite implant cylinders for tibial bone defects in senile, osteopenic sheep.
Sachse A, Hasenbein I, Hortschansky P, Schmuck KD, Maenz S, Illerhaus B, Kuehmstedt P, Ramm R, Huber R, Kunisch E, Horbert V, Gunnella F, Roth A, Schubert H, Kinne RW. Sachse A, et al. Among authors: hasenbein i. J Mater Sci Mater Med. 2023 Jun 28;34(7):31. doi: 10.1007/s10856-023-06734-2. J Mater Sci Mater Med. 2023. PMID: 37378714 Free PMC article.
Single Application of Low-Dose, Hydroxyapatite-Bound BMP-2 or GDF-5 Induces Long-Term Bone Formation and Biomechanical Stabilization of a Bone Defect in a Senile Sheep Lumbar Osteopenia Model.
Hasenbein I, Sachse A, Hortschansky P, Schmuck KD, Horbert V, Anders C, Lehmann T, Huber R, Maslaris A, Layher F, Braun C, Roth A, Plöger F, Kinne RW. Hasenbein I, et al. Biomedicines. 2022 Feb 21;10(2):513. doi: 10.3390/biomedicines10020513. Biomedicines. 2022. PMID: 35203721 Free PMC article.
The old sheep: a convenient and suitable model for senile osteopenia.
Maenz S, Brinkmann O, Hasenbein I, Braun C, Kunisch E, Horbert V, Gunnella F, Sachse A, Bischoff S, Schubert H, Jandt KD, Bossert J, Driesch D, Kinne RW, Bungartz M. Maenz S, et al. Among authors: hasenbein i. J Bone Miner Metab. 2020 Sep;38(5):620-630. doi: 10.1007/s00774-020-01098-x. Epub 2020 Apr 15. J Bone Miner Metab. 2020. PMID: 32296985