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In vivo methods for drug absorption - comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects.
Sjögren E, Abrahamsson B, Augustijns P, Becker D, Bolger MB, Brewster M, Brouwers J, Flanagan T, Harwood M, Heinen C, Holm R, Juretschke HP, Kubbinga M, Lindahl A, Lukacova V, Münster U, Neuhoff S, Nguyen MA, Peer Av, Reppas C, Hodjegan AR, Tannergren C, Weitschies W, Wilson C, Zane P, Lennernäs H, Langguth P. Sjögren E, et al. Among authors: harwood m. Eur J Pharm Sci. 2014 Jun 16;57:99-151. doi: 10.1016/j.ejps.2014.02.010. Epub 2014 Mar 15. Eur J Pharm Sci. 2014. PMID: 24637348 Review.
In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-Glycoprotein and Breast Cancer Resistance Protein: Part I: A Cross-Laboratory Comparison of Transporter-Protein Abundances and Relative Expression Factors in Human Intestine and Caco-2 Cells.
Harwood MD, Achour B, Neuhoff S, Russell MR, Carlson G, Warhurst G; Amin Rostami-Hodjegan. Harwood MD, et al. Drug Metab Dispos. 2016 Mar;44(3):297-307. doi: 10.1124/dmd.115.067371. Epub 2015 Dec 2. Drug Metab Dispos. 2016. PMID: 26631742
In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition.
Harwood MD, Achour B, Neuhoff S, Russell MR, Carlson G, Warhurst G, Rostami-Hodjegan A. Harwood MD, et al. Drug Metab Dispos. 2016 Mar;44(3):476-80. doi: 10.1124/dmd.115.067777. Epub 2016 Feb 3. Drug Metab Dispos. 2016. PMID: 26842595
Abundance of Hepatic Transporters in Caucasians: A Meta-Analysis.
Burt HJ, Riedmaier AE, Harwood MD, Crewe HK, Gill KL, Neuhoff S. Burt HJ, et al. Drug Metab Dispos. 2016 Oct;44(10):1550-61. doi: 10.1124/dmd.116.071183. Epub 2016 Aug 4. Drug Metab Dispos. 2016. PMID: 27493152 Free PMC article.
323 results