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Copy number variants (CNVs): a powerful tool for iPSC-based modelling of ASD.
Drakulic D, Djurovic S, Syed YA, Trattaro S, Caporale N, Falk A, Ofir R, Heine VM, Chawner SJRA, Rodriguez-Moreno A, van den Bree MBM, Testa G, Petrakis S, Harwood AJ. Drakulic D, et al. Among authors: harwood aj. Mol Autism. 2020 Jun 1;11(1):42. doi: 10.1186/s13229-020-00343-4. Mol Autism. 2020. PMID: 32487215 Free PMC article. Review.
Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants.
Sanders B, D'Andrea D, Collins MO, Rees E, Steward TGJ, Zhu Y, Chapman G, Legge SE, Pardiñas AF, Harwood AJ, Gray WP, O'Donovan MC, Owen MJ, Errington AC, Blake DJ, Whitcomb DJ, Pocklington AJ, Shin E. Sanders B, et al. Among authors: harwood aj. Nat Commun. 2022 Jan 14;13(1):27. doi: 10.1038/s41467-021-27601-0. Nat Commun. 2022. PMID: 35031607 Free PMC article.
NRSF/REST lies at the intersection between epigenetic regulation, miRNA-mediated gene control and neurodevelopmental pathways associated with Intellectual disability (ID) and Schizophrenia.
Alsaqati M, Davis BA, Wood J, Jones MM, Jones L, Westwood A, Petter O, Isles AR, Linden D, Van den Bree M, Owen M, Hall J, Harwood AJ. Alsaqati M, et al. Among authors: harwood aj. Transl Psychiatry. 2022 Oct 10;12(1):438. doi: 10.1038/s41398-022-02199-z. Transl Psychiatry. 2022. PMID: 36216811 Free PMC article.
Modeling psychiatric disorders: from genomic findings to cellular phenotypes.
Falk A, Heine VM, Harwood AJ, Sullivan PF, Peitz M, Brüstle O, Shen S, Sun YM, Glover JC, Posthuma D, Djurovic S. Falk A, et al. Among authors: harwood aj. Mol Psychiatry. 2016 Sep;21(9):1167-79. doi: 10.1038/mp.2016.89. Epub 2016 May 31. Mol Psychiatry. 2016. PMID: 27240529 Free PMC article. Review.
104 results