Hartmann RW - Search Results

1

17β-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer.

Gargano EM, Mohamed A, Abdelsamie AS, Mangiatordi GF, Drzewiecka H, Jagodziński PP, Mazzini A, van Koppen CJ, Laschke MW, Nicolotti O, Carotti A, Marchais-Oberwinkler S, Hartmann RW, Frotscher M. Gargano EM, et al. Among authors: hartmann rw. ACS Med Chem Lett. 2021 Nov 18;12(12):1920-1924. doi: 10.1021/acsmedchemlett.1c00462. eCollection 2021 Dec 9. ACS Med Chem Lett. 2021. PMID: 34917255 Free PMC article.

2

1-Imidazolylcarbonyloxy-substituted tetrahydroquinolines and pyridines: synthesis and evaluation of P450 TxA2 inhibition.

Hartmann RW, Frotscher M. Hartmann RW, et al. Arch Pharm (Weinheim). 1999 Oct;332(10):358-62. doi: 10.1002/(sici)1521-4184(199910)332:10<358::aid-ardp358>3.0.co;2-d. Arch Pharm (Weinheim). 1999. PMID: 10575369

3

1-imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: syntheses and evaluation of dual inhibitors of thromboxane A(2) synthase and aromatase.

Jacobs C, Frotscher M, Dannhardt G, Hartmann RW. Jacobs C, et al. Among authors: hartmann rw. J Med Chem. 2000 May 4;43(9):1841-51. doi: 10.1021/jm991180u. J Med Chem. 2000. PMID: 10794700

4

Synthesis of amidinohydrazones and evaluation of their inhibitory effect towards aldosterone synthase (CYP11B2) and the formation of selected steroids.

Voets M, Müller-Vieira U, Marchais-Oberwinkler S, Hartmann RW. Voets M, et al. Among authors: hartmann rw. Arch Pharm (Weinheim). 2004 Jul;337(7):411-6. doi: 10.1002/ardp.200400872. Arch Pharm (Weinheim). 2004. PMID: 15237392

5

Design, synthesis, and 3D QSAR of novel potent and selective aromatase inhibitors.

Leonetti F, Favia A, Rao A, Aliano R, Paluszcak A, Hartmann RW, Carotti A. Leonetti F, et al. Among authors: hartmann rw. J Med Chem. 2004 Dec 30;47(27):6792-803. doi: 10.1021/jm049535j. J Med Chem. 2004. PMID: 15615528

6

Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis.

Voets M, Antes I, Scherer C, Müller-Vieira U, Biemel K, Barassin C, Marchais-Oberwinkler S, Hartmann RW. Voets M, et al. Among authors: hartmann rw. J Med Chem. 2005 Oct 20;48(21):6632-42. doi: 10.1021/jm0503704. J Med Chem. 2005. PMID: 16220979

7

Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids.

Salem OI, Frotscher M, Scherer C, Neugebauer A, Biemel K, Streiber M, Maas R, Hartmann RW. Salem OI, et al. Among authors: hartmann rw. J Med Chem. 2006 Jan 26;49(2):748-59. doi: 10.1021/jm050728w. J Med Chem. 2006. PMID: 16420060

8

Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis.

Voets M, Antes I, Scherer C, Müller-Vieira U, Biemel K, Marchais-Oberwinkler S, Hartmann RW. Voets M, et al. Among authors: hartmann rw. J Med Chem. 2006 Apr 6;49(7):2222-31. doi: 10.1021/jm060055x. J Med Chem. 2006. PMID: 16570918

9

Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases.

Frotscher M, Ziegler E, Marchais-Oberwinkler S, Kruchten P, Neugebauer A, Fetzer L, Scherer C, Müller-Vieira U, Messinger J, Thole H, Hartmann RW. Frotscher M, et al. Among authors: hartmann rw. J Med Chem. 2008 Apr 10;51(7):2158-69. doi: 10.1021/jm701447v. Epub 2008 Mar 7. J Med Chem. 2008. PMID: 18324762

10

Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases.

Bey E, Marchais-Oberwinkler S, Kruchten P, Frotscher M, Werth R, Oster A, Algül O, Neugebauer A, Hartmann RW. Bey E, et al. Among authors: hartmann rw. Bioorg Med Chem. 2008 Jun 15;16(12):6423-35. doi: 10.1016/j.bmc.2008.04.073. Epub 2008 May 3. Bioorg Med Chem. 2008. PMID: 18514529

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