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IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy.
Zhou T, Damsky W, Weizman OE, McGeary MK, Hartmann KP, Rosen CE, Fischer S, Jackson R, Flavell RA, Wang J, Sanmamed MF, Bosenberg MW, Ring AM. Zhou T, et al. Among authors: hartmann kp. Nature. 2020 Jul;583(7817):609-614. doi: 10.1038/s41586-020-2422-6. Epub 2020 Jun 24. Nature. 2020. PMID: 32581358 Free PMC article.
NK cells with tissue-resident traits shape response to immunotherapy by inducing adaptive antitumor immunity.
Kirchhammer N, Trefny MP, Natoli M, Brücher D, Smith SN, Werner F, Koch V, Schreiner D, Bartoszek E, Buchi M, Schmid M, Breu D, Hartmann KP, Zaytseva P, Thommen DS, Läubli H, Böttcher JP, Stanczak MA, Kashyap AS, Plückthun A, Zippelius A. Kirchhammer N, et al. Among authors: hartmann kp. Sci Transl Med. 2022 Jul 13;14(653):eabm9043. doi: 10.1126/scitranslmed.abm9043. Epub 2022 Jul 13. Sci Transl Med. 2022. PMID: 35857639 Free article.
Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action.
Kast F, Schwill M, Stüber JC, Pfundstein S, Nagy-Davidescu G, Rodríguez JMM, Seehusen F, Richter CP, Honegger A, Hartmann KP, Weber TG, Kroener F, Ernst P, Piehler J, Plückthun A. Kast F, et al. Among authors: hartmann kp. Nat Commun. 2021 Jun 18;12(1):3790. doi: 10.1038/s41467-021-23948-6. Nat Commun. 2021. PMID: 34145240 Free PMC article.
Targeted adenovirus-mediated transduction of human T cells in vitro and in vivo.
Freitag PC, Kaulfuss M, Flühler L, Mietz J, Weiss F, Brücher D, Kolibius J, Hartmann KP, Smith SN, Münz C, Chijioke O, Plückthun A. Freitag PC, et al. Among authors: hartmann kp. Mol Ther Methods Clin Dev. 2023 Feb 26;29:120-132. doi: 10.1016/j.omtm.2023.02.012. eCollection 2023 Jun 8. Mol Ther Methods Clin Dev. 2023. PMID: 37007608 Free PMC article.