Hart CE - Search Results

1

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index.

Shen W, De Hoyos CL, Migawa MT, Vickers TA, Sun H, Low A, Bell TA 3rd, Rahdar M, Mukhopadhyay S, Hart CE, Bell M, Riney S, Murray SF, Greenlee S, Crooke RM, Liang XH, Seth PP, Crooke ST. Shen W, et al. Among authors: hart ce. Nat Biotechnol. 2019 Jun;37(6):640-650. doi: 10.1038/s41587-019-0106-2. Epub 2019 Apr 29. Nat Biotechnol. 2019. PMID: 31036929

2

Transfection of siRNAs can alter miRNA levels and trigger non-specific protein degradation in mammalian cells.

Liang XH, Hart CE, Crooke ST. Liang XH, et al. Among authors: hart ce. Biochim Biophys Acta. 2013 May;1829(5):455-68. doi: 10.1016/j.bbagrm.2013.01.011. Epub 2013 Feb 8. Biochim Biophys Acta. 2013. PMID: 23403288 Free article.

3

Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages.

Wan WB, Migawa MT, Vasquez G, Murray HM, Nichols JG, Gaus H, Berdeja A, Lee S, Hart CE, Lima WF, Swayze EE, Seth PP. Wan WB, et al. Among authors: hart ce. Nucleic Acids Res. 2014 Dec 16;42(22):13456-68. doi: 10.1093/nar/gku1115. Epub 2014 Nov 14. Nucleic Acids Res. 2014. PMID: 25398895 Free PMC article.

4

Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts.

Burel SA, Hart CE, Cauntay P, Hsiao J, Machemer T, Katz M, Watt A, Bui HH, Younis H, Sabripour M, Freier SM, Hung G, Dan A, Prakash TP, Seth PP, Swayze EE, Bennett CF, Crooke ST, Henry SP. Burel SA, et al. Among authors: hart ce. Nucleic Acids Res. 2016 Mar 18;44(5):2093-109. doi: 10.1093/nar/gkv1210. Epub 2015 Nov 8. Nucleic Acids Res. 2016. PMID: 26553810 Free PMC article.

5

Viable RNaseH1 knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function.

Lima WF, Murray HM, Damle SS, Hart CE, Hung G, De Hoyos CL, Liang XH, Crooke ST. Lima WF, et al. Among authors: hart ce. Nucleic Acids Res. 2016 Jun 20;44(11):5299-312. doi: 10.1093/nar/gkw350. Epub 2016 Apr 29. Nucleic Acids Res. 2016. PMID: 27131367 Free PMC article.

6

Integrated Safety Assessment of 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers.

Crooke ST, Baker BF, Kwoh TJ, Cheng W, Schulz DJ, Xia S, Salgado N, Bui HH, Hart CE, Burel SA, Younis HS, Geary RS, Henry SP, Bhanot S. Crooke ST, et al. Among authors: hart ce. Mol Ther. 2016 Oct;24(10):1771-1782. doi: 10.1038/mt.2016.136. Epub 2016 Jun 30. Mol Ther. 2016. PMID: 27357629 Free PMC article.

7

A modular analysis of microglia gene expression, insights into the aged phenotype.

Cho CE, Damle SS, Wancewicz EV, Mukhopadhyay S, Hart CE, Mazur C, Swayze EE, Kamme F. Cho CE, et al. Among authors: hart ce. BMC Genomics. 2019 Feb 28;20(1):164. doi: 10.1186/s12864-019-5549-9. BMC Genomics. 2019. PMID: 30819113 Free PMC article.

8

GOLGA8 increases bulk antisense oligonucleotide uptake and activity in mammalian cells.

McMahon MA, Rahdar M, Mukhopadhyay S, Bui HH, Hart C, Damle S, Courtney M, Baughn MW, Cleveland DW, Bennett CF. McMahon MA, et al. Mol Ther Nucleic Acids. 2023 Mar 27;32:289-301. doi: 10.1016/j.omtn.2023.03.017. eCollection 2023 Jun 13. Mol Ther Nucleic Acids. 2023. PMID: 37096163 Free PMC article.

9

Antisense oligonucleotide treatment ameliorates IFN-γ-induced proteinuria in APOL1-transgenic mice.

Aghajan M, Booten SL, Althage M, Hart CE, Ericsson A, Maxvall I, Ochaba J, Menschik-Lundin A, Hartleib J, Kuntz S, Gattis D, Ahlström C, Watt AT, Engelhardt JA, Monia BP, Magnone MC, Guo S. Aghajan M, et al. Among authors: hart ce. JCI Insight. 2019 Jun 20;4(12):e126124. doi: 10.1172/jci.insight.126124. eCollection 2019 Jun 20. JCI Insight. 2019. PMID: 31217349 Free PMC article.

10

Antisense Oligonucleotides Targeting Jagged 1 Reduce House Dust Mite-induced Goblet Cell Metaplasia in the Adult Murine Lung.

Carrer M, Crosby JR, Sun G, Zhao C, Damle SS, Kuntz SG, Monia BP, Hart CE, Grossman TR. Carrer M, et al. Among authors: hart ce. Am J Respir Cell Mol Biol. 2020 Jul;63(1):46-56. doi: 10.1165/rcmb.2019-0257OC. Am J Respir Cell Mol Biol. 2020. PMID: 32176858

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