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The activin A antagonist follistatin inhibits asthmatic airway remodelling.
Hardy CL, Nguyen HA, Mohamud R, Yao J, Oh DY, Plebanski M, Loveland KL, Harrison CA, Rolland JM, O'Hehir RE. Hardy CL, et al. Among authors: harrison ca. Thorax. 2013 Jan;68(1):9-18. doi: 10.1136/thoraxjnl-2011-201128. Epub 2012 Oct 10. Thorax. 2013. PMID: 23051972
Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice.
Winbanks CE, Murphy KT, Bernardo BC, Qian H, Liu Y, Sepulveda PV, Beyer C, Hagg A, Thomson RE, Chen JL, Walton KL, Loveland KL, McMullen JR, Rodgers BD, Harrison CA, Lynch GS, Gregorevic P. Winbanks CE, et al. Among authors: harrison ca. Sci Transl Med. 2016 Jul 20;8(348):348ra98. doi: 10.1126/scitranslmed.aac4976. Sci Transl Med. 2016. PMID: 27440729
Therapeutic blockade of activin-A improves NK cell function and antitumor immunity.
Rautela J, Dagley LF, de Oliveira CC, Schuster IS, Hediyeh-Zadeh S, Delconte RB, Cursons J, Hennessy R, Hutchinson DS, Harrison C, Kita B, Vivier E, Webb AI, Degli-Esposti MA, Davis MJ, Huntington ND, Souza-Fonseca-Guimaraes F. Rautela J, et al. Sci Signal. 2019 Aug 27;12(596):eaat7527. doi: 10.1126/scisignal.aat7527. Sci Signal. 2019. PMID: 31455725
Development of novel activin-targeted therapeutics.
Chen JL, Walton KL, Al-Musawi SL, Kelly EK, Qian H, La M, Lu L, Lovrecz G, Ziemann M, Lazarus R, El-Osta A, Gregorevic P, Harrison CA. Chen JL, et al. Among authors: harrison ca. Mol Ther. 2015 Mar;23(3):434-44. doi: 10.1038/mt.2014.221. Epub 2014 Nov 17. Mol Ther. 2015. PMID: 25399825 Free PMC article.
150 results