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Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion.
Oh CJ, Kim MJ, Lee JM, Kim DH, Kim IY, Park S, Kim Y, Lee KB, Lee SH, Lim CW, Kim M, Lee JY, Pagire HS, Pagire SH, Bae MA, Chanda D, Thoudam T, Khang AR, Harris RA, Ahn JH, Jeon JH, Lee IK. Oh CJ, et al. Among authors: harris ra. Kidney Int. 2023 Oct;104(4):724-739. doi: 10.1016/j.kint.2023.06.022. Epub 2023 Jul 1. Kidney Int. 2023. PMID: 37399974
Noncanonical PDK4 action alters mitochondrial dynamics to affect the cellular respiratory status.
Thoudam T, Chanda D, Sinam IS, Kim BG, Kim MJ, Oh CJ, Lee JY, Kim MJ, Park SY, Lee SY, Jung MK, Mun JY, Harris RA, Ishihara N, Jeon JH, Lee IK. Thoudam T, et al. Among authors: harris ra. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2120157119. doi: 10.1073/pnas.2120157119. Epub 2022 Aug 15. Proc Natl Acad Sci U S A. 2022. PMID: 35969774 Free PMC article.
Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis.
Go Y, Jeong JY, Jeoung NH, Jeon JH, Park BY, Kang HJ, Ha CM, Choi YK, Lee SJ, Ham HJ, Kim BG, Park KG, Park SY, Lee CH, Choi CS, Park TS, Lee WN, Harris RA, Lee IK. Go Y, et al. Among authors: harris ra. Diabetes. 2016 Oct;65(10):2876-87. doi: 10.2337/db16-0223. Epub 2016 Jul 6. Diabetes. 2016. PMID: 27385159
Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype.
Min BK, Park S, Kang HJ, Kim DW, Ham HJ, Ha CM, Choi BJ, Lee JY, Oh CJ, Yoo EK, Kim HE, Kim BG, Jeon JH, Hyeon DY, Hwang D, Kim YH, Lee CH, Lee T, Kim JW, Choi YK, Park KG, Chawla A, Lee J, Harris RA, Lee IK. Min BK, et al. Among authors: harris ra. Front Immunol. 2019 May 7;10:944. doi: 10.3389/fimmu.2019.00944. eCollection 2019. Front Immunol. 2019. PMID: 31134063 Free PMC article.
1,332 results