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Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.
Xia D, Lianoglou S, Sandmann T, Calvert M, Suh JH, Thomsen E, Dugas J, Pizzo ME, DeVos SL, Earr TK, Lin CC, Davis S, Ha C, Leung AW, Nguyen H, Chau R, Yulyaningsih E, Lopez I, Solanoy H, Masoud ST, Liang CC, Lin K, Astarita G, Khoury N, Zuchero JY, Thorne RG, Shen K, Miller S, Palop JJ, Garceau D, Sasner M, Whitesell JD, Harris JA, Hummel S, Gnörich J, Wind K, Kunze L, Zatcepin A, Brendel M, Willem M, Haass C, Barnett D, Zimmer TS, Orr AG, Scearce-Levie K, Lewcock JW, Di Paolo G, Sanchez PE. Xia D, et al. Among authors: harris ja. Mol Neurodegener. 2022 Jun 11;17(1):41. doi: 10.1186/s13024-022-00547-7. Mol Neurodegener. 2022. PMID: 35690868 Free PMC article.
Reversing EphB2 depletion rescues cognitive functions in Alzheimer model.
Cissé M, Halabisky B, Harris J, Devidze N, Dubal DB, Sun B, Orr A, Lotz G, Kim DH, Hamto P, Ho K, Yu GQ, Mucke L. Cissé M, et al. Nature. 2011 Jan 6;469(7328):47-52. doi: 10.1038/nature09635. Epub 2010 Nov 28. Nature. 2011. PMID: 21113149 Free PMC article.
High-resolution data-driven model of the mouse connectome.
Knox JE, Harris KD, Graddis N, Whitesell JD, Zeng H, Harris JA, Shea-Brown E, Mihalas S. Knox JE, et al. Among authors: harris kd, harris ja. Netw Neurosci. 2018 Dec 1;3(1):217-236. doi: 10.1162/netn_a_00066. eCollection 2019. Netw Neurosci. 2018. PMID: 30793081 Free PMC article.
A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease.
Davis EJ, Broestl L, Abdulai-Saiku S, Worden K, Bonham LW, Miñones-Moyano E, Moreno AJ, Wang D, Chang K, Williams G, Garay BI, Lobach I, Devidze N, Kim D, Anderson-Bergman C, Yu GQ, White CC, Harris JA, Miller BL, Bennett DA, Arnold AP, De Jager PL, Palop JJ, Panning B, Yokoyama JS, Mucke L, Dubal DB. Davis EJ, et al. Among authors: harris ja. Sci Transl Med. 2020 Aug 26;12(558):eaaz5677. doi: 10.1126/scitranslmed.aaz5677. Sci Transl Med. 2020. PMID: 32848093 Free PMC article.
Endogenous pathology in tauopathy mice progresses via brain networks.
Ramirez DMO, Whitesell JD, Bhagwat N, Thomas TL, Ajay AD, Nawaby A, Delatour B, Bay S, LaFaye P, Knox JE, Harris JA, Meeks JP, Diamond MI. Ramirez DMO, et al. Among authors: harris ja. bioRxiv [Preprint]. 2023 May 24:2023.05.23.541792. doi: 10.1101/2023.05.23.541792. bioRxiv. 2023. PMID: 37293074 Free PMC article. Preprint.
635 results