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A common variant of the p16(INK4a) genetic region is associated with physical function in older people.
Melzer D, Frayling TM, Murray A, Hurst AJ, Harries LW, Song H, Khaw K, Luben R, Surtees PG, Bandinelli SS, Corsi AM, Ferrucci L, Guralnik JM, Wallace RB, Hattersley AT, Pharoah PD. Melzer D, et al. Among authors: harries lw. Mech Ageing Dev. 2007 May-Jun;128(5-6):370-7. doi: 10.1016/j.mad.2007.03.005. Epub 2007 Mar 27. Mech Ageing Dev. 2007. PMID: 17459456 Free PMC article.
Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association.
Wood AR, Hernandez DG, Nalls MA, Yaghootkar H, Gibbs JR, Harries LW, Chong S, Moore M, Weedon MN, Guralnik JM, Bandinelli S, Murray A, Ferrucci L, Singleton AB, Melzer D, Frayling TM. Wood AR, et al. Among authors: harries lw. Hum Mol Genet. 2011 Oct 15;20(20):4082-92. doi: 10.1093/hmg/ddr328. Epub 2011 Jul 28. Hum Mol Genet. 2011. PMID: 21798870 Free PMC article.
Bisphenol A exposure is associated with in vivo estrogenic gene expression in adults.
Melzer D, Harries L, Cipelli R, Henley W, Money C, McCormack P, Young A, Guralnik J, Ferrucci L, Bandinelli S, Corsi AM, Galloway T. Melzer D, et al. Environ Health Perspect. 2011 Dec;119(12):1788-93. doi: 10.1289/ehp.1103809. Epub 2011 Aug 10. Environ Health Perspect. 2011. PMID: 21831745 Free PMC article.
Genomics and successful aging: grounds for renewed optimism?
Pilling LC, Harries LW, Powell J, Llewellyn DJ, Ferrucci L, Melzer D. Pilling LC, et al. Among authors: harries lw. J Gerontol A Biol Sci Med Sci. 2012 May;67(5):511-9. doi: 10.1093/gerona/gls091. Epub 2012 Mar 27. J Gerontol A Biol Sci Med Sci. 2012. PMID: 22454374 Free PMC article. Review.
Towards a gene expression biomarker set for human biological age.
Holly AC, Melzer D, Pilling LC, Henley W, Hernandez DG, Singleton AB, Bandinelli S, Guralnik JM, Ferrucci L, Harries LW. Holly AC, et al. Among authors: harries lw. Aging Cell. 2013 Apr;12(2):324-6. doi: 10.1111/acel.12044. Epub 2013 Jan 30. Aging Cell. 2013. PMID: 23311345 Free PMC article.
146 results