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Pharmacological, Pharmacokinetic, Pharmacodynamic and Physicochemical Characterization of FE 205030: A Potent, Fast Acting, Injectable CGRP Receptor Antagonist for the Treatment of Acute Episodic Migraine.
Srinivasan K, Kozminski K, Zhang Y, Wisniewski K, Kohout T, Wisniewska H, Harris G, Lindstrom B, Hargrove D. Srinivasan K, et al. Among authors: hargrove d. J Pharm Sci. 2022 Jan;111(1):247-261. doi: 10.1016/j.xphs.2021.06.034. Epub 2021 Jul 2. J Pharm Sci. 2022. PMID: 34217775
Discovery of Potent, Selective, and Short-Acting Peptidic V2 Receptor Agonists.
Wiśniewski K, Qi S, Kraus J, Ly B, Srinivasan K, Tariga H, Croston G, La E, Wiśniewska H, Ortiz C, Laporte R, Rivière PJ, Neyer G, Hargrove DM, Schteingart CD. Wiśniewski K, et al. Among authors: hargrove dm. J Med Chem. 2019 May 23;62(10):4991-5005. doi: 10.1021/acs.jmedchem.9b00132. Epub 2019 May 7. J Med Chem. 2019. PMID: 31022340
Pharmacological Characterization of Apraglutide, a Novel Long-Acting Peptidic Glucagon-Like Peptide-2 Agonist, for the Treatment of Short Bowel Syndrome.
Hargrove DM, Alagarsamy S, Croston G, Laporte R, Qi S, Srinivasan K, Sueiras-Diaz J, Wiśniewski K, Hartwig J, Lu M, Posch AP, Wiśniewska H, Schteingart CD, Rivière PJ, Dimitriadou V. Hargrove DM, et al. J Pharmacol Exp Ther. 2020 May;373(2):193-203. doi: 10.1124/jpet.119.262238. Epub 2020 Feb 19. J Pharmacol Exp Ther. 2020. PMID: 32075870
Synthesis and Pharmacological Characterization of Novel Glucagon-like Peptide-2 (GLP-2) Analogues with Low Systemic Clearance.
Wiśniewski K, Sueiras-Diaz J, Jiang G, Galyean R, Lu M, Thompson D, Wang YC, Croston G, Posch A, Hargrove DM, Wiśniewska H, Laporte R, Dwyer JJ, Qi S, Srinivasan K, Hartwig J, Ferdyan N, Mares M, Kraus J, Alagarsamy S, Rivière PJ, Schteingart CD. Wiśniewski K, et al. Among authors: hargrove dm. J Med Chem. 2016 Apr 14;59(7):3129-39. doi: 10.1021/acs.jmedchem.5b01909. Epub 2016 Mar 25. J Med Chem. 2016. PMID: 26986178
Biological activity of AC3174, a peptide analog of exendin-4.
Hargrove DM, Kendall ES, Reynolds JM, Lwin AN, Herich JP, Smith PA, Gedulin BR, Flanagan SD, Jodka CM, Hoyt JA, McCowen KM, Parkes DG, Anderson CM. Hargrove DM, et al. Regul Pept. 2007 Jun 7;141(1-3):113-9. doi: 10.1016/j.regpep.2006.12.021. Epub 2007 Jan 11. Regul Pept. 2007. PMID: 17292977
A novel long-acting glucose-dependent insulinotropic peptide analogue: enhanced efficacy in normal and diabetic rodents.
Tatarkiewicz K, Hargrove DM, Jodka CM, Gedulin BR, Smith PA, Hoyt JA, Lwin A, Collins L, Mamedova L, Levy OE, D'Souza L, Janssen S, Srivastava V, Ghosh SS, Parkes DG. Tatarkiewicz K, et al. Among authors: d souza l, hargrove dm. Diabetes Obes Metab. 2014 Jan;16(1):75-85. doi: 10.1111/dom.12181. Epub 2013 Aug 19. Diabetes Obes Metab. 2014. PMID: 23859463 Free PMC article.
Discovery of N-benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an orally active, gut-selective CCK1 receptor agonist for the potential treatment of obesity.
Elliott RL, Cameron KO, Chin JE, Bartlett JA, Beretta EE, Chen Y, Jardine Pda S, Dubins JS, Gillaspy ML, Hargrove DM, Kalgutkar AS, LaFlamme JA, Lame ME, Martin KA, Maurer TS, Nardone NA, Oliver RM, Scott DO, Sun D, Swick AG, Trebino CE, Zhang Y. Elliott RL, et al. Among authors: hargrove dm. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6797-801. doi: 10.1016/j.bmcl.2010.08.115. Epub 2010 Sep 28. Bioorg Med Chem Lett. 2010. PMID: 20851601
90 results