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Exoenzyme Y Contributes to End-Organ Dysfunction Caused by Pseudomonas aeruginosa Pneumonia in Critically Ill Patients: An Exploratory Study.
Toxins (Basel). 2020 Jun 4;12(6):369. doi: 10.3390/toxins12060369.
Toxins (Basel). 2020.
PMID: 32512716
Free PMC article.
Perspectives on the Pseudomonas aeruginosa Type III Secretion System Effector ExoU and Its Subversion of the Host Innate Immune Response to Infection.
Hardy KS, Tessmer MH, Frank DW, Audia JP.
Hardy KS, et al.
Toxins (Basel). 2021 Dec 9;13(12):880. doi: 10.3390/toxins13120880.
Toxins (Basel). 2021.
PMID: 34941717
Free PMC article.
Review.
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ExoU Induces Lung Endothelial Cell Damage and Activates Pro-Inflammatory Caspase-1 during Pseudomonas aeruginosa Infection.
Hardy KS, Tuckey AN, Renema P, Patel M, Al-Mehdi AB, Spadafora D, Schlumpf CA, Barrington RA, Alexeyev MF, Stevens T, Pittet JF, Wagener BM, Simmons JD, Alvarez DF, Audia JP.
Hardy KS, et al.
Toxins (Basel). 2022 Feb 18;14(2):152. doi: 10.3390/toxins14020152.
Toxins (Basel). 2022.
PMID: 35202178
Free PMC article.
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The Pseudomonas aeruginosa Type III Secretion System Exoenzyme Effector ExoU Induces Mitochondrial Damage in a Murine Bone Marrow-Derived Macrophage Infection Model.
Hardy KS, Tuckey AN, Housley NA, Andrews J, Patel M, Al-Mehdi AB, Barrington RA, Cassel SL, Sutterwala FS, Audia JP.
Hardy KS, et al.
Infect Immun. 2022 Mar 17;90(3):e0047021. doi: 10.1128/IAI.00470-21. Epub 2022 Feb 7.
Infect Immun. 2022.
PMID: 35130452
Free PMC article.
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cAMP signaling primes lung endothelial cells to activate caspase-1 during Pseudomonas aeruginosa infection.
Renema P, Hardy KS, Housley N, Dunbar G, Annamdevula N, Britain A, Spadafora D, Leavesley S, Rich T, Audia JP, Alvarez DF.
Renema P, et al. Among authors: hardy ks.
Am J Physiol Lung Cell Mol Physiol. 2020 May 1;318(5):L1074-L1083. doi: 10.1152/ajplung.00185.2019. Epub 2020 Mar 18.
Am J Physiol Lung Cell Mol Physiol. 2020.
PMID: 32186399
Free PMC article.
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Screen for Modulation of Nucleocapsid Protein Condensation Identifies Small Molecules with Anti-Coronavirus Activity.
Quek RT, Hardy KS, Walker SG, Nguyen DT, de Almeida Magalhães T, Salic A, Gopalakrishnan SM, Silver PA, Mitchison TJ.
Quek RT, et al. Among authors: hardy ks.
ACS Chem Biol. 2023 Mar 17;18(3):583-594. doi: 10.1021/acschembio.2c00908. Epub 2023 Feb 16.
ACS Chem Biol. 2023.
PMID: 36795767
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