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Factor inhibiting HIF can catalyze two asparaginyl hydroxylations in VNVN motifs of ankyrin fold proteins.
Leissing TM, Hardy AP, Chan H, Wang Y, Tumber A, Chowdhury R, Feng T, Coleman ML, Cockman ME, Kramer HB, Berridge G, Fischer R, Kessler BM, Ratcliffe PJ, Lu X, Schofield CJ. Leissing TM, et al. Among authors: hardy ap. J Biol Chem. 2022 Jun;298(6):102020. doi: 10.1016/j.jbc.2022.102020. Epub 2022 May 7. J Biol Chem. 2022. PMID: 35537551 Free PMC article.
Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans.
Ge W, Wolf A, Feng T, Ho CH, Sekirnik R, Zayer A, Granatino N, Cockman ME, Loenarz C, Loik ND, Hardy AP, Claridge TDW, Hamed RB, Chowdhury R, Gong L, Robinson CV, Trudgian DC, Jiang M, Mackeen MM, Mccullagh JS, Gordiyenko Y, Thalhammer A, Yamamoto A, Yang M, Liu-Yi P, Zhang Z, Schmidt-Zachmann M, Kessler BM, Ratcliffe PJ, Preston GM, Coleman ML, Schofield CJ. Ge W, et al. Among authors: hardy ap. Nat Chem Biol. 2012 Dec;8(12):960-962. doi: 10.1038/nchembio.1093. Epub 2012 Oct 28. Nat Chem Biol. 2012. PMID: 23103944 Free PMC article.
Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.
Leung IK, Demetriades M, Hardy AP, Lejeune C, Smart TJ, Szöllössi A, Kawamura A, Schofield CJ, Claridge TD. Leung IK, et al. Among authors: hardy ap. J Med Chem. 2013 Jan 24;56(2):547-55. doi: 10.1021/jm301583m. Epub 2013 Jan 4. J Med Chem. 2013. PMID: 23234607 Free PMC article.
Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor.
Yang M, Hardy AP, Chowdhury R, Loik ND, Scotti JS, McCullagh JS, Claridge TD, McDonough MA, Ge W, Schofield CJ. Yang M, et al. Among authors: hardy ap. Angew Chem Int Ed Engl. 2013 Feb 4;52(6):1700-4. doi: 10.1002/anie.201208046. Epub 2013 Jan 7. Angew Chem Int Ed Engl. 2013. PMID: 23296631 No abstract available.
17 results