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Single-particle cryo-EM at atomic resolution.
Nakane T, Kotecha A, Sente A, McMullan G, Masiulis S, Brown PMGE, Grigoras IT, Malinauskaite L, Malinauskas T, Miehling J, Uchański T, Yu L, Karia D, Pechnikova EV, de Jong E, Keizer J, Bischoff M, McCormack J, Tiemeijer P, Hardwick SW, Chirgadze DY, Murshudov G, Aricescu AR, Scheres SHW. Nakane T, et al. Among authors: hardwick sw. Nature. 2020 Nov;587(7832):152-156. doi: 10.1038/s41586-020-2829-0. Epub 2020 Oct 21. Nature. 2020. PMID: 33087931 Free PMC article.
CryoEM structures of human CMG-ATPγS-DNA and CMG-AND-1 complexes.
Rzechorzek NJ, Hardwick SW, Jatikusumo VA, Chirgadze DY, Pellegrini L. Rzechorzek NJ, et al. Among authors: hardwick sw. Nucleic Acids Res. 2020 Jul 9;48(12):6980-6995. doi: 10.1093/nar/gkaa429. Nucleic Acids Res. 2020. PMID: 32453425 Free PMC article.
Dimers of DNA-PK create a stage for DNA double-strand break repair.
Chaplin AK, Hardwick SW, Liang S, Kefala Stavridi A, Hnizda A, Cooper LR, De Oliveira TM, Chirgadze DY, Blundell TL. Chaplin AK, et al. Among authors: hardwick sw. Nat Struct Mol Biol. 2021 Jan;28(1):13-19. doi: 10.1038/s41594-020-00517-x. Epub 2020 Oct 19. Nat Struct Mol Biol. 2021. PMID: 33077952
Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Chaplin AK, Hardwick SW, Stavridi AK, Buehl CJ, Goff NJ, Ropars V, Liang S, De Oliveira TM, Chirgadze DY, Meek K, Charbonnier JB, Blundell TL. Chaplin AK, et al. Among authors: hardwick sw. Mol Cell. 2021 Aug 19;81(16):3400-3409.e3. doi: 10.1016/j.molcel.2021.07.005. Epub 2021 Aug 4. Mol Cell. 2021. PMID: 34352203 Free PMC article.
Mechanisms of inhibition and activation of extrasynaptic αβ GABAA receptors.
Kasaragod VB, Mortensen M, Hardwick SW, Wahid AA, Dorovykh V, Chirgadze DY, Smart TG, Miller PS. Kasaragod VB, et al. Among authors: hardwick sw. Nature. 2022 Feb;602(7897):529-533. doi: 10.1038/s41586-022-04402-z. Epub 2022 Feb 9. Nature. 2022. PMID: 35140402 Free PMC article.
Differential assembly diversifies GABAA receptor structures and signalling.
Sente A, Desai R, Naydenova K, Malinauskas T, Jounaidi Y, Miehling J, Zhou X, Masiulis S, Hardwick SW, Chirgadze DY, Miller KW, Aricescu AR. Sente A, et al. Among authors: hardwick sw. Nature. 2022 Apr;604(7904):190-194. doi: 10.1038/s41586-022-04517-3. Epub 2022 Mar 30. Nature. 2022. PMID: 35355020 Free PMC article.
49 results