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TMPRSS2 Is the Major Activating Protease of Influenza A Virus in Primary Human Airway Cells and Influenza B Virus in Human Type II Pneumocytes.
Limburg H, Harbig A, Bestle D, Stein DA, Moulton HM, Jaeger J, Janga H, Hardes K, Koepke J, Schulte L, Koczulla AR, Schmeck B, Klenk HD, Böttcher-Friebertshäuser E. Limburg H, et al. Among authors: hardes k. J Virol. 2019 Oct 15;93(21):e00649-19. doi: 10.1128/JVI.00649-19. Print 2019 Nov 1. J Virol. 2019. PMID: 31391268 Free PMC article.
Novel Furin Inhibitors with Potent Anti-infectious Activity.
Hardes K, Becker GL, Lu Y, Dahms SO, Köhler S, Beyer W, Sandvig K, Yamamoto H, Lindberg I, Walz L, von Messling V, Than ME, Garten W, Steinmetzer T. Hardes K, et al. ChemMedChem. 2015 Jul;10(7):1218-31. doi: 10.1002/cmdc.201500103. Epub 2015 May 14. ChemMedChem. 2015. PMID: 25974265
Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells.
Lu Y, Hardes K, Dahms SO, Böttcher-Friebertshäuser E, Steinmetzer T, Than ME, Klenk HD, Garten W. Lu Y, et al. Among authors: hardes k. Antiviral Res. 2015 Aug;120:89-100. doi: 10.1016/j.antiviral.2015.05.006. Epub 2015 May 26. Antiviral Res. 2015. PMID: 26022200
Optimization of Substrate-Analogue Furin Inhibitors.
Ivanova T, Hardes K, Kallis S, Dahms SO, Than ME, Künzel S, Böttcher-Friebertshäuser E, Lindberg I, Jiao GS, Bartenschlager R, Steinmetzer T. Ivanova T, et al. Among authors: hardes k. ChemMedChem. 2017 Dec 7;12(23):1953-1968. doi: 10.1002/cmdc.201700596. Epub 2017 Nov 16. ChemMedChem. 2017. PMID: 29059503
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells.
Bestle D, Heindl MR, Limburg H, Van Lam van T, Pilgram O, Moulton H, Stein DA, Hardes K, Eickmann M, Dolnik O, Rohde C, Klenk HD, Garten W, Steinmetzer T, Böttcher-Friebertshäuser E. Bestle D, et al. Among authors: hardes k. Life Sci Alliance. 2020 Jul 23;3(9):e202000786. doi: 10.26508/lsa.202000786. Print 2020 Sep. Life Sci Alliance. 2020. PMID: 32703818 Free PMC article.
40 results