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DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling.
Harapas CR, Robinson KS, Lay K, Wong J, Moreno Traspas R, Nabavizadeh N, Rass-Rothschild A, Boisson B, Drutman SB, Laohamonthonkul P, Bonner D, Xiong JR, Gorrell MD, Davidson S, Yu CH, Fleming MD, Gudera J, Stein J, Ben-Harosh M, Groopman E, Shimamura A, Tamary H, Kayserili H, Hatipoğlu N, Casanova JL, Bernstein JA, Zhong FL, Masters SL, Reversade B. Harapas CR, et al. Sci Immunol. 2022 Sep 16;7(75):eabi4611. doi: 10.1126/sciimmunol.abi4611. Epub 2022 Sep 16. Sci Immunol. 2022. PMID: 36112693 Free PMC article.
Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding.
Zhong FL, Robinson K, Teo DET, Tan KY, Lim C, Harapas CR, Yu CH, Xie WH, Sobota RM, Au VB, Hopkins R, D'Osualdo A, Reed JC, Connolly JE, Masters SL, Reversade B. Zhong FL, et al. Among authors: harapas cr. J Biol Chem. 2018 Dec 7;293(49):18864-18878. doi: 10.1074/jbc.RA118.004350. Epub 2018 Oct 5. J Biol Chem. 2018. PMID: 30291141 Free PMC article.
NLRP1 variant M1184V decreases inflammasome activation in the context of DPP9 inhibition and asthma severity.
Moecking J, Laohamonthonkul P, Chalker K, White MJ, Harapas CR, Yu CH, Davidson S, Hrovat-Schaale K, Hu D, Eng C, Huntsman S, Calleja DJ, Horvat JC, Hansbro PM, O'Donoghue RJJ, Ting JP, Burchard EG, Geyer M, Gerlic M, Masters SL. Moecking J, et al. Among authors: harapas cr. J Allergy Clin Immunol. 2021 Jun;147(6):2134-2145.e20. doi: 10.1016/j.jaci.2020.12.636. Epub 2020 Dec 27. J Allergy Clin Immunol. 2021. PMID: 33378691 Free PMC article.
ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome.
Robinson KS, Toh GA, Rozario P, Chua R, Bauernfried S, Sun Z, Firdaus MJ, Bayat S, Nadkarni R, Poh ZS, Tham KC, Harapas CR, Lim CK, Chu W, Tay CWS, Tan KY, Zhao T, Bonnard C, Sobota R, Connolly JE, Common J, Masters SL, Chen KW, Ho L, Wu B, Hornung V, Zhong FL. Robinson KS, et al. Among authors: harapas cr. Science. 2022 Jul 15;377(6603):328-335. doi: 10.1126/science.abl6324. Epub 2022 Jul 14. Science. 2022. PMID: 35857590 Free PMC article.
An Update on Autoinflammatory Diseases: Interferonopathies.
Davidson S, Steiner A, Harapas CR, Masters SL. Davidson S, et al. Among authors: harapas cr. Curr Rheumatol Rep. 2018 May 30;20(7):38. doi: 10.1007/s11926-018-0748-y. Curr Rheumatol Rep. 2018. PMID: 29846818 Review.
An Update on Autoinflammatory Diseases: Relopathies.
Steiner A, Harapas CR, Masters SL, Davidson S. Steiner A, et al. Among authors: harapas cr. Curr Rheumatol Rep. 2018 May 30;20(7):39. doi: 10.1007/s11926-018-0749-x. Curr Rheumatol Rep. 2018. PMID: 29846841 Review.
NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease.
Tye H, Yu CH, Simms LA, de Zoete MR, Kim ML, Zakrzewski M, Penington JS, Harapas CR, Souza-Fonseca-Guimaraes F, Wockner LF, Preaudet A, Mielke LA, Wilcox SA, Ogura Y, Corr SC, Kanojia K, Kouremenos KA, De Souza DP, McConville MJ, Flavell RA, Gerlic M, Kile BT, Papenfuss AT, Putoczki TL, Radford-Smith GL, Masters SL. Tye H, et al. Among authors: harapas cr. Nat Commun. 2018 Sep 13;9(1):3728. doi: 10.1038/s41467-018-06125-0. Nat Commun. 2018. PMID: 30214011 Free PMC article.
Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24.
Davidson S, Yu CH, Steiner A, Ebstein F, Baker PJ, Jarur-Chamy V, Hrovat Schaale K, Laohamonthonkul P, Kong K, Calleja DJ, Harapas CR, Balka KR, Mitchell J, Jackson JT, Geoghegan ND, Moghaddas F, Rogers KL, Mayer-Barber KD, De Jesus AA, De Nardo D, Kile BT, Sadler AJ, Poli MC, Krüger E, Goldbach Mansky R, Masters SL. Davidson S, et al. Among authors: harapas cr. Sci Immunol. 2022 Feb 11;7(68):eabi6763. doi: 10.1126/sciimmunol.abi6763. Epub 2022 Feb 11. Sci Immunol. 2022. PMID: 35148201 Free PMC article.
Organellar homeostasis and innate immune sensing.
Harapas CR, Idiiatullina E, Al-Azab M, Hrovat-Schaale K, Reygaerts T, Steiner A, Laohamonthonkul P, Davidson S, Yu CH, Booty L, Masters SL. Harapas CR, et al. Nat Rev Immunol. 2022 Sep;22(9):535-549. doi: 10.1038/s41577-022-00682-8. Epub 2022 Feb 23. Nat Rev Immunol. 2022. PMID: 35197578 Review.
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