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SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response.
Tsuji S, Minami S, Hashimoto R, Konishi Y, Suzuki T, Kondo T, Sasai M, Torii S, Ono C, Shichinohe S, Sato S, Wakita M, Okumura S, Nakano S, Matsudaira T, Matsumoto T, Kawamoto S, Yamamoto M, Watanabe T, Matsuura Y, Takayama K, Kobayashi T, Okamoto T, Hara E. Tsuji S, et al. Among authors: hara e. Nat Aging. 2022 Feb;2(2):115-124. doi: 10.1038/s43587-022-00170-7. Epub 2022 Jan 25. Nat Aging. 2022. PMID: 37117754 Free PMC article.
Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer.
Miyata K, Imai Y, Hori S, Nishio M, Loo TM, Okada R, Yang L, Nakadai T, Maruyama R, Fujii R, Ueda K, Jiang L, Zheng H, Toyokuni S, Sakata T, Shirahige K, Kojima R, Nakayama M, Oshima M, Nagayama S, Seimiya H, Hirota T, Saya H, Hara E, Takahashi A. Miyata K, et al. Among authors: hara e. Proc Natl Acad Sci U S A. 2021 Aug 31;118(35):e2025647118. doi: 10.1073/pnas.2025647118. Proc Natl Acad Sci U S A. 2021. PMID: 34426493 Free PMC article.
Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion.
Okumura S, Konishi Y, Narukawa M, Sugiura Y, Yoshimoto S, Arai Y, Sato S, Yoshida Y, Tsuji S, Uemura K, Wakita M, Matsudaira T, Matsumoto T, Kawamoto S, Takahashi A, Itatani Y, Miki H, Takamatsu M, Obama K, Takeuchi K, Suematsu M, Ohtani N, Fukunaga Y, Ueno M, Sakai Y, Nagayama S, Hara E. Okumura S, et al. Among authors: hara e. Nat Commun. 2021 Sep 28;12(1):5674. doi: 10.1038/s41467-021-25965-x. Nat Commun. 2021. PMID: 34584098 Free PMC article.
Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis.
Yamamoto-Imoto H, Minami S, Shioda T, Yamashita Y, Sakai S, Maeda S, Yamamoto T, Oki S, Takashima M, Yamamuro T, Yanagawa K, Edahiro R, Iwatani M, So M, Tokumura A, Abe T, Imamura R, Nonomura N, Okada Y, Ayer DE, Ogawa H, Hara E, Takabatake Y, Isaka Y, Nakamura S, Yoshimori T. Yamamoto-Imoto H, et al. Among authors: hara e. Cell Rep. 2022 Mar 1;38(9):110444. doi: 10.1016/j.celrep.2022.110444. Cell Rep. 2022. PMID: 35235784 Free article.
345 results