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Page 1
Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis.
Becker K, Cao S, Nilsson A, Erlandsson M, Hotop SK, Kuka J, Hansen J, Haldimann K, Grinberga S, Berruga-Fernández T, Huseby DL, Shariatgorji R, Lindmark E, Platzack B, Böttger EC, Crich D, Friberg LE, Vingsbo Lundberg C, Hughes D, Brönstrup M, Andrén PE, Liepinsh E, Hobbie SN. Becker K, et al. Among authors: hansen j. EBioMedicine. 2021 Nov;73:103652. doi: 10.1016/j.ebiom.2021.103652. Epub 2021 Nov 2. EBioMedicine. 2021. PMID: 34740109 Free PMC article.
Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin.
Sou T, Hansen J, Liepinsh E, Backlund M, Ercan O, Grinberga S, Cao S, Giachou P, Petersson A, Tomczak M, Urbas M, Zabicka D, Vingsbo Lundberg C, Hughes D, Hobbie SN, Friberg LE. Sou T, et al. Among authors: hansen j. Clin Pharmacol Ther. 2021 Apr;109(4):1063-1073. doi: 10.1002/cpt.2104. Epub 2020 Nov 28. Clin Pharmacol Ther. 2021. PMID: 33150591 Free PMC article.
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors.
Brem J, Panduwawala T, Hansen JU, Hewitt J, Liepins E, Donets P, Espina L, Farley AJM, Shubin K, Campillos GG, Kiuru P, Shishodia S, Krahn D, Leśniak RK, Schmidt Adrian J, Calvopiña K, Turrientes MC, Kavanagh ME, Lubriks D, Hinchliffe P, Langley GW, Aboklaish AF, Eneroth A, Backlund M, Baran AG, Nielsen EI, Speake M, Kuka J, Robinson J, Grinberga S, Robinson L, McDonough MA, Rydzik AM, Leissing TM, Jimenez-Castellanos JC, Avison MB, Da Silva Pinto S, Pannifer AD, Martjuga M, Widlake E, Priede M, Hopkins Navratilova I, Gniadkowski M, Belfrage AK, Brandt P, Yli-Kauhaluoma J, Bacque E, Page MGP, Björkling F, Tyrrell JM, Spencer J, Lang PA, Baranczewski P, Cantón R, McElroy SP, Jones PS, Baquero F, Suna E, Morrison A, Walsh TR, Schofield CJ. Brem J, et al. Among authors: hansen ju. Nat Chem. 2022 Jan;14(1):15-24. doi: 10.1038/s41557-021-00831-x. Epub 2021 Dec 13. Nat Chem. 2022. PMID: 34903857
Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia.
Aranzana-Climent V, Hughes D, Cao S, Tomczak M, Urbas M, Zabicka D, Vingsbo Lundberg C, Hansen J, Lindberg J, Hobbie SN, Friberg LE. Aranzana-Climent V, et al. Among authors: hansen j. Clin Microbiol Infect. 2022 Oct;28(10):1367-1374. doi: 10.1016/j.cmi.2022.05.003. Epub 2022 May 20. Clin Microbiol Infect. 2022. PMID: 35598857 Free article.
Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections.
Arrazuria R, Kerscher B, Huber KE, Hoover JL, Lundberg CV, Hansen JU, Sordello S, Renard S, Aranzana-Climent V, Hughes D, Gribbon P, Friberg LE, Bekeredjian-Ding I. Arrazuria R, et al. Front Microbiol. 2022 Sep 8;13:988725. doi: 10.3389/fmicb.2022.988725. eCollection 2022. Front Microbiol. 2022. PMID: 36160186 Free PMC article.
Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents.
Arrazuria R, Kerscher B, Huber KE, Hoover JL, Lundberg CV, Hansen JU, Sordello S, Renard S, Aranzana-Climent V, Hughes D, Gribbon P, Friberg LE, Bekeredjian-Ding I. Arrazuria R, et al. Front Microbiol. 2022 Sep 8;13:988728. doi: 10.3389/fmicb.2022.988728. eCollection 2022. Front Microbiol. 2022. PMID: 36160241 Free PMC article. Review.
Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine blood stream infection models.
Frimodt-Møller N, Hansen JU, Plattner M, Huseby DL, Almind SR, Haldimann K, Gysin M, Petersson A, Ercan O, Ganz L, Hughes D, Lundberg CV, Hobbie SN. Frimodt-Møller N, et al. Int J Antimicrob Agents. 2024 Apr 21:107181. doi: 10.1016/j.ijantimicag.2024.107181. Online ahead of print. Int J Antimicrob Agents. 2024. PMID: 38653351 Free article.
Topical niclosamide (ATx201) reduces Staphylococcus aureus colonization and increases Shannon diversity of the skin microbiome in atopic dermatitis patients in a randomized, double-blind, placebo-controlled Phase 2 trial.
Weiss A, Delavenne E, Matias C, Lagler H, Simon D, Li P, Hansen JU, Dos Santos TP, Jana B, Priemel P, Bangert C, Bauer M, Eberl S, Nussbaumer-Pröll A, Anne Österreicher Z, Matzneller P, Quint T, Weber M, Nielsen HM, Rades T, Johansen HK, Westh H, Kim W, Mylonakis E, Friis C, Guardabassi L, Pace J, Lundberg CV, M'Zali F, Butty P, Sørensen N, Nielsen HB, Toft-Kehler R, Guttman-Yassky E, Stingl G, Zeitlinger M, Sommer M. Weiss A, et al. Among authors: hansen ju. Clin Transl Med. 2022 May;12(5):e790. doi: 10.1002/ctm2.790. Clin Transl Med. 2022. PMID: 35522900 Free PMC article. Clinical Trial.
Critical aortic stenosis - The long-term burden.
Voges I, Hansen JH. Voges I, et al. Among authors: hansen jh. Int J Cardiol. 2024 May 3:132134. doi: 10.1016/j.ijcard.2024.132134. Online ahead of print. Int J Cardiol. 2024. PMID: 38705208 No abstract available.
6,454 results