Hannun YA - Search Results

1

Neutral ceramidase-active site inhibitor chemotypes and binding modes.

Coant N, Bickel JD, Rahaim R, Otsuka Y, Choi YM, Xu R, Simoes M, Cariello C, Mao C, Saied EM, Arenz C, Spicer TP, Bannister TD, Tonge PJ, Airola MV, Scampavia L, Hannun YA, Rizzo RC, Haley JD. Coant N, et al. Among authors: hannun ya. Bioorg Chem. 2023 Oct;139:106747. doi: 10.1016/j.bioorg.2023.106747. Epub 2023 Jul 27. Bioorg Chem. 2023. PMID: 37531819 Free PMC article.

2

A simple, highly sensitive, and facile method to quantify ceramide at the plasma membrane.

Greene M, Hernandez-Corbacho MJ, Ostermeyer-Fay AG, Hannun YA, Canals D. Greene M, et al. Among authors: hannun ya. J Lipid Res. 2023 Feb;64(2):100322. doi: 10.1016/j.jlr.2022.100322. Epub 2022 Dec 20. J Lipid Res. 2023. PMID: 36549592 Free PMC article.

3

Targeting acid ceramidase ameliorates fibrosis in mouse models of non-alcoholic steatohepatitis.

Yu A, Cable C, Sharma S, Shihan MH, Mattis AN, Mileva I, Hannun YA, Duwaerts CC, Chen JY. Yu A, et al. Among authors: hannun ya. Front Med (Lausanne). 2022 Oct 6;9:881848. doi: 10.3389/fmed.2022.881848. eCollection 2022. Front Med (Lausanne). 2022. PMID: 36275798 Free PMC article.

4

Biological function, topology, and quantification of plasma membrane Ceramide.

Canals D, Hannun YA. Canals D, et al. Among authors: hannun ya. Adv Biol Regul. 2024 Jan;91:101009. doi: 10.1016/j.jbior.2023.101009. Epub 2023 Dec 14. Adv Biol Regul. 2024. PMID: 38128364 Review.

5

The heat shock protein Hsp27 controls mitochondrial function by modulating ceramide generation.

Boyd RA, Majumder S, Stiban J, Mavodza G, Straus AJ, Kempelingaiah SK, Reddy V, Hannun YA, Obeid LM, Senkal CE. Boyd RA, et al. Among authors: hannun ya. Cell Rep. 2023 Sep 26;42(9):113081. doi: 10.1016/j.celrep.2023.113081. Epub 2023 Sep 8. Cell Rep. 2023. PMID: 37689067 Free PMC article.

6

Upregulation of sphingosine kinase 1 in response to doxorubicin generates an angiogenic response via stabilization of Snail.

Bonica J, Clarke CJ, Obeid LM, Luberto C, Hannun YA. Bonica J, et al. Among authors: hannun ya. FASEB J. 2023 Mar;37(3):e22787. doi: 10.1096/fj.202201066R. FASEB J. 2023. PMID: 36723905 Free PMC article.

7

Expression of Ceramide Synthases in Mice and Their Roles in Regulating Acyl-Chain Sphingolipids: A Framework for Baseline Levels and Future Implications in Aging and Disease.

Richardson WJ, Humphrey SB, Sears SM, Hoffman NA, Orwick AJ, Doll MA, Doll CL, Xia C, Hernandez-Corbacho M, Snider JM, Obeid LM, Hannun YA, Snider AJ, Siskind LJ. Richardson WJ, et al. Among authors: hannun ya. Mol Pharmacol. 2024 Feb 15;105(3):131-143. doi: 10.1124/molpharm.123.000788. Mol Pharmacol. 2024. PMID: 38164625 Free PMC article.

8

A transcriptional network governing ceramide homeostasis establishes a cytokine-dependent developmental process.

Liao R, Babatunde A, Qiu S, Harikumar H, Coon JJ, Overmyer KA, Hannun YA, Luberto C, Bresnick EH. Liao R, et al. Among authors: hannun ya. Nat Commun. 2023 Nov 9;14(1):7262. doi: 10.1038/s41467-023-42978-w. Nat Commun. 2023. PMID: 37945603 Free PMC article.

9

Neutral Sphingomyelinase 2 Inhibition Limits Hepatic Steatosis and Inflammation.

Al-Rashed F, Arefanian H, Madhoun AA, Bahman F, Sindhu S, AlSaeed H, Jacob T, Thomas R, Al-Roub A, Alzaid F, Malik MDZ, Nizam R, Thanaraj TA, Al-Mulla F, Hannun YA, Ahmad R. Al-Rashed F, et al. Among authors: hannun ya. Cells. 2024 Mar 6;13(5):463. doi: 10.3390/cells13050463. Cells. 2024. PMID: 38474427 Free PMC article.

10

Targeting sphingosine kinase 1 in p53KO thymic lymphoma.

Velazquez FN, Stith JL, Zhang L, Allam AM, Haley J, Obeid LM, Snider AJ, Hannun YA. Velazquez FN, et al. Among authors: hannun ya. FASEB J. 2023 Nov;37(11):e23247. doi: 10.1096/fj.202301417R. FASEB J. 2023. PMID: 37800872

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