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NUDT22 promotes cancer growth through pyrimidine salvage.
Oncogene. 2023 Apr;42(16):1282-1293. doi: 10.1038/s41388-023-02643-4. Epub 2023 Mar 4.
Oncogene. 2023.
PMID: 36871087
Free PMC article.
Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.
Michel M, Benítez-Buelga C, Calvo PA, Hanna BMF, Mortusewicz O, Masuyer G, Davies J, Wallner O, Sanjiv K, Albers JJ, Castañeda-Zegarra S, Jemth AS, Visnes T, Sastre-Perona A, Danda AN, Homan EJ, Marimuthu K, Zhenjun Z, Chi CN, Sarno A, Wiita E, von Nicolai C, Komor AJ, Rajagopal V, Müller S, Hank EC, Varga M, Scaletti ER, Pandey M, Karsten S, Haslene-Hox H, Loevenich S, Marttila P, Rasti A, Mamonov K, Ortis F, Schömberg F, Loseva O, Stewart J, D'Arcy-Evans N, Koolmeister T, Henriksson M, Michel D, de Ory A, Acero L, Calvete O, Scobie M, Hertweck C, Vilotijevic I, Kalderén C, Osorio A, Perona R, Stolz A, Stenmark P, Berglund UW, de Vega M, Helleday T.
Michel M, et al. Among authors: hanna bmf.
Science. 2022 Jun 24;376(6600):1471-1476. doi: 10.1126/science.abf8980. Epub 2022 Jun 23.
Science. 2022.
PMID: 35737787
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NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487.
Hanna BMF, Michel M, Helleday T, Mortusewicz O.
Hanna BMF, et al.
Int J Mol Sci. 2021 Apr 27;22(9):4542. doi: 10.3390/ijms22094542.
Int J Mol Sci. 2021.
PMID: 33925271
Free PMC article.
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Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects.
Baquero JM, Benítez-Buelga C, Rajagopal V, Zhenjun Z, Torres-Ruiz R, Müller S, Hanna BMF, Loseva O, Wallner O, Michel M, Rodríguez-Perales S, Gad H, Visnes T, Helleday T, Benítez J, Osorio A.
Baquero JM, et al. Among authors: hanna bmf.
Sci Rep. 2021 Feb 10;11(1):3490. doi: 10.1038/s41598-021-82917-7.
Sci Rep. 2021.
PMID: 33568707
Free PMC article.
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Targeting OGG1 arrests cancer cell proliferation by inducing replication stress.
Visnes T, Benítez-Buelga C, Cázares-Körner A, Sanjiv K, Hanna BMF, Mortusewicz O, Rajagopal V, Albers JJ, Hagey DW, Bekkhus T, Eshtad S, Baquero JM, Masuyer G, Wallner O, Müller S, Pham T, Göktürk C, Rasti A, Suman S, Torres-Ruiz R, Sarno A, Wiita E, Homan EJ, Karsten S, Marimuthu K, Michel M, Koolmeister T, Scobie M, Loseva O, Almlöf I, Unterlass JE, Pettke A, Boström J, Pandey M, Gad H, Herr P, Jemth AS, El Andaloussi S, Kalderén C, Rodriguez-Perales S, Benítez J, Krokan HE, Altun M, Stenmark P, Berglund UW, Helleday T.
Visnes T, et al. Among authors: hanna bmf.
Nucleic Acids Res. 2020 Dec 2;48(21):12234-12251. doi: 10.1093/nar/gkaa1048.
Nucleic Acids Res. 2020.
PMID: 33211885
Free PMC article.
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OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions.
Hanna BMF, Helleday T, Mortusewicz O.
Hanna BMF, et al.
Biomolecules. 2020 Oct 26;10(11):1483. doi: 10.3390/biom10111483.
Biomolecules. 2020.
PMID: 33114607
Free PMC article.
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Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.
Visnes T, Cázares-Körner A, Hao W, Wallner O, Masuyer G, Loseva O, Mortusewicz O, Wiita E, Sarno A, Manoilov A, Astorga-Wells J, Jemth AS, Pan L, Sanjiv K, Karsten S, Gokturk C, Grube M, Homan EJ, Hanna BMF, Paulin CBJ, Pham T, Rasti A, Berglund UW, von Nicolai C, Benitez-Buelga C, Koolmeister T, Ivanic D, Iliev P, Scobie M, Krokan HE, Baranczewski P, Artursson P, Altun M, Jensen AJ, Kalderén C, Ba X, Zubarev RA, Stenmark P, Boldogh I, Helleday T.
Visnes T, et al. Among authors: hanna bmf.
Science. 2018 Nov 16;362(6416):834-839. doi: 10.1126/science.aar8048.
Science. 2018.
PMID: 30442810
Free PMC article.
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Targeting BER enzymes in cancer therapy.
Visnes T, Grube M, Hanna BMF, Benitez-Buelga C, Cázares-Körner A, Helleday T.
Visnes T, et al. Among authors: hanna bmf.
DNA Repair (Amst). 2018 Nov;71:118-126. doi: 10.1016/j.dnarep.2018.08.015. Epub 2018 Aug 25.
DNA Repair (Amst). 2018.
PMID: 30228084
Free article.
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