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Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity.
Jenkins BJ, Blagih J, Ponce-Garcia FM, Canavan M, Gudgeon N, Eastham S, Hill D, Hanlon MM, Ma EH, Bishop EL, Rees A, Cronin JG, Jury EC, Dimeloe SK, Veale DJ, Thornton CA, Vousden KH, Finlay DK, Fearon U, Jones GW, Sinclair LV, Vincent EE, Jones N. Jenkins BJ, et al. Among authors: hanlon mm. Cell Metab. 2023 Jul 11;35(7):1132-1146.e9. doi: 10.1016/j.cmet.2023.05.001. Epub 2023 May 24. Cell Metab. 2023. PMID: 37230079 Free article.
Rheumatoid arthritis CD14+ monocytes display metabolic and inflammatory dysfunction, a phenotype that precedes clinical manifestation of disease.
McGarry T, Hanlon MM, Marzaioli V, Cunningham CC, Krishna V, Murray K, Hurson C, Gallagher P, Nagpal S, Veale DJ, Fearon U. McGarry T, et al. Among authors: hanlon mm. Clin Transl Immunology. 2021 Jan 19;10(1):e1237. doi: 10.1002/cti2.1237. eCollection 2021. Clin Transl Immunology. 2021. PMID: 33510894 Free PMC article.
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