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Mouse macrophages completely lacking Rho subfamily GTPases (RhoA, RhoB, and RhoC) have severe lamellipodial retraction defects, but robust chemotactic navigation and altered motility.
Königs V, Jennings R, Vogl T, Horsthemke M, Bachg AC, Xu Y, Grobe K, Brakebusch C, Schwab A, Bähler M, Knaus UG, Hanley PJ. Königs V, et al. Among authors: hanley pj. J Biol Chem. 2014 Oct 31;289(44):30772-30784. doi: 10.1074/jbc.M114.563270. Epub 2014 Sep 11. J Biol Chem. 2014. PMID: 25213860 Free PMC article.
A novel isoform of myosin 18A (Myo18Aγ) is an essential sarcomeric protein in mouse heart.
Horsthemke M, Nutter LMJ, Bachg AC, Skryabin BV, Honnert U, Zobel T, Bogdan S, Stoll M, Seidl MD, Müller FU, Ravens U, Unger A, Linke WA, van Gorp PRR, de Vries AAF, Bähler M, Hanley PJ. Horsthemke M, et al. Among authors: hanley pj. J Biol Chem. 2019 May 3;294(18):7202-7218. doi: 10.1074/jbc.RA118.004560. Epub 2019 Feb 8. J Biol Chem. 2019. PMID: 30737279 Free PMC article.
Time-lapse Imaging of Mouse Macrophage Chemotaxis.
van den Bos E, Walbaum S, Horsthemke M, Bachg AC, Hanley PJ. van den Bos E, et al. Among authors: hanley pj. J Vis Exp. 2020 Apr 2;(158). doi: 10.3791/60750. J Vis Exp. 2020. PMID: 32310228
151 results