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PI3K: A master regulator of brain metastasis-promoting macrophages/microglia.
Blazquez R, Wlochowitz D, Wolff A, Seitz S, Wachter A, Perera-Bel J, Bleckmann A, Beißbarth T, Salinas G, Riemenschneider MJ, Proescholdt M, Evert M, Utpatel K, Siam L, Schatlo B, Balkenhol M, Stadelmann C, Schildhaus HU, Korf U, Reinz E, Wiemann S, Vollmer E, Schulz M, Ritter U, Hanisch UK, Pukrop T. Blazquez R, et al. Among authors: hanisch uk. Glia. 2018 Nov;66(11):2438-2455. doi: 10.1002/glia.23485. Epub 2018 Oct 25. Glia. 2018. PMID: 30357946
Carcinoma cells misuse the host tissue damage response to invade the brain.
Chuang HN, van Rossum D, Sieger D, Siam L, Klemm F, Bleckmann A, Bayerlová M, Farhat K, Scheffel J, Schulz M, Dehghani F, Stadelmann C, Hanisch UK, Binder C, Pukrop T. Chuang HN, et al. Among authors: hanisch uk. Glia. 2013 Aug;61(8):1331-46. doi: 10.1002/glia.22518. Epub 2013 Jul 6. Glia. 2013. PMID: 23832647 Free PMC article.
LEF1 supports metastatic brain colonization by regulating glutathione metabolism and increasing ROS resistance in breast cancer.
Blazquez R, Rietkötter E, Wenske B, Wlochowitz D, Sparrer D, Vollmer E, Müller G, Seegerer J, Sun X, Dettmer K, Barrantes-Freer A, Stange L, Utpatel K, Bleckmann A, Treiber H, Bohnenberger H, Lenz C, Schulz M, Reimelt C, Hackl C, Grade M, Büyüktas D, Siam L, Balkenhol M, Stadelmann C, Kube D, Krahn MP, Proescholdt MA, Riemenschneider MJ, Evert M, Oefner PJ, Klein CA, Hanisch UK, Binder C, Pukrop T. Blazquez R, et al. Among authors: hanisch uk. Int J Cancer. 2020 Jun 1;146(11):3170-3183. doi: 10.1002/ijc.32742. Epub 2019 Nov 11. Int J Cancer. 2020. PMID: 31626715 Free article.
Intralesional TLR4 agonist treatment strengthens the organ defense against colonizing cancer cells in the brain.
Blazquez R, Chuang HN, Wenske B, Trigueros L, Wlochowitz D, Liguori R, Ferrazzi F, Regen T, Proescholdt MA, Rohde V, Riemenschneider MJ, Stadelmann C, Bleckmann A, Beißbarth T, van Rossum D, Hanisch UK, Pukrop T. Blazquez R, et al. Among authors: hanisch uk. Oncogene. 2022 Nov;41(46):5008-5019. doi: 10.1038/s41388-022-02496-3. Epub 2022 Oct 12. Oncogene. 2022. PMID: 36224342 Free PMC article.
Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia.
Scheffel J, Regen T, Van Rossum D, Seifert S, Ribes S, Nau R, Parsa R, Harris RA, Boddeke HW, Chuang HN, Pukrop T, Wessels JT, Jürgens T, Merkler D, Brück W, Schnaars M, Simons M, Kettenmann H, Hanisch UK. Scheffel J, et al. Among authors: hanisch uk. Glia. 2012 Dec;60(12):1930-43. doi: 10.1002/glia.22409. Epub 2012 Aug 21. Glia. 2012. PMID: 22911652
Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism.
Menzfeld C, John M, van Rossum D, Regen T, Scheffel J, Janova H, Götz A, Ribes S, Nau R, Borisch A, Boutin P, Neumann K, Bremes V, Wienands J, Reichardt HM, Lühder F, Tischner D, Waetzig V, Herdegen T, Teismann P, Greig I, Müller M, Pukrop T, Mildner A, Kettenmann H, Brück W, Prinz M, Rotshenker S, Weber MS, Hanisch UK. Menzfeld C, et al. Among authors: hanisch uk. Glia. 2015 Jun;63(6):1083-99. doi: 10.1002/glia.22803. Epub 2015 Mar 2. Glia. 2015. PMID: 25731696
CD14 is a key organizer of microglial responses to CNS infection and injury.
Janova H, Böttcher C, Holtman IR, Regen T, van Rossum D, Götz A, Ernst AS, Fritsche C, Gertig U, Saiepour N, Gronke K, Wrzos C, Ribes S, Rolfes S, Weinstein J, Ehrenreich H, Pukrop T, Kopatz J, Stadelmann C, Salinas-Riester G, Weber MS, Prinz M, Brück W, Eggen BJ, Boddeke HW, Priller J, Hanisch UK. Janova H, et al. Among authors: hanisch uk. Glia. 2016 Apr;64(4):635-49. doi: 10.1002/glia.22955. Epub 2015 Dec 18. Glia. 2016. PMID: 26683584
114 results