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Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW. Zhao F, et al. Among authors: hang k. Nat Commun. 2022 Feb 25;13(1):1057. doi: 10.1038/s41467-022-28683-0. Nat Commun. 2022. PMID: 35217653 Free PMC article.
Full-length human GLP-1 receptor structure without orthosteric ligands.
Wu F, Yang L, Hang K, Laursen M, Wu L, Han GW, Ren Q, Roed NK, Lin G, Hanson MA, Jiang H, Wang MW, Reedtz-Runge S, Song G, Stevens RC. Wu F, et al. Among authors: hang k. Nat Commun. 2020 Mar 9;11(1):1272. doi: 10.1038/s41467-020-14934-5. Nat Commun. 2020. PMID: 32152292 Free PMC article.
Molecular basis of signal transduction mediated by the human GIPR splice variants.
Zhao F, Hang K, Zhou Q, Shao L, Li H, Li W, Lin S, Dai A, Cai X, Liu Y, Xu Y, Feng W, Yang D, Wang MW. Zhao F, et al. Among authors: hang k. Proc Natl Acad Sci U S A. 2023 Oct 10;120(41):e2306145120. doi: 10.1073/pnas.2306145120. Epub 2023 Oct 4. Proc Natl Acad Sci U S A. 2023. PMID: 37792509 Free PMC article.
38 results