Handzlik J - Search Results

1

Aspects of a Distinct Cytotoxicity of Selenium Salts and Organic Selenides in Living Cells with Possible Implications for Drug Design.

Estevam EC, Witek K, Faulstich L, Nasim MJ, Latacz G, Domínguez-Álvarez E, Kieć-Kononowicz K, Demasi M, Handzlik J, Jacob C. Estevam EC, et al. Among authors: handzlik j. Molecules. 2015 Jul 31;20(8):13894-912. doi: 10.3390/molecules200813894. Molecules. 2015. PMID: 26263963 Free PMC article.

2

Discovery of novel arylpiperazine-based DA/5-HT modulators as potential antipsychotic agents - Design, synthesis, structural studies and pharmacological profiling.

Stępnicki P, Targowska-Duda KM, Martínez AL, Zięba A, Wronikowska-Denysiuk O, Wróbel MZ, Bartyzel A, Trzpil A, Wróbel TM, Chodkowski A, Mirecka K, Karcz T, Szczepańska K, Loza MI, Budzyńska B, Turło J, Handzlik J, Fornal E, Poleszak E, Castro M, Kaczor AA. Stępnicki P, et al. Among authors: handzlik j. Eur J Med Chem. 2023 Apr 5;252:115285. doi: 10.1016/j.ejmech.2023.115285. Epub 2023 Mar 17. Eur J Med Chem. 2023. PMID: 37027998

3

Funnel metadynamics and behavioral studies reveal complex effect of D2AAK1 ligand on anxiety-like processes.

Bartuzi D, Kędzierska E, Targowska-Duda KM, Koszła O, Wróbel TM, Jademyr S, Karcz T, Szczepańska K, Stępnicki P, Wronikowska-Denysiuk O, Biała G, Handzlik J, Kristensen JL, Poso A, Kaczor AA. Bartuzi D, et al. Among authors: handzlik j. Sci Rep. 2022 Dec 7;12(1):21192. doi: 10.1038/s41598-022-25478-7. Sci Rep. 2022. PMID: 36476619 Free PMC article.

4

Synthesis and evaluation of in vivo activity of diphenylhydantoin basic derivatives.

Dylag T, Zygmunt M, Maciag D, Handzlik J, Bednarski M, Filipek B, Kieć-Kononowicz K. Dylag T, et al. Among authors: handzlik j. Eur J Med Chem. 2004 Dec;39(12):1013-27. doi: 10.1016/j.ejmech.2004.05.008. Eur J Med Chem. 2004. PMID: 15571863

5

Synthesis, alpha 1-adrenoceptor antagonist activity, and SAR study of novel arylpiperazine derivatives of phenytoin.

Handzlik J, Maciag D, Kubacka M, Mogilski S, Filipek B, Stadnicka K, Kieć-Kononowicz K. Handzlik J, et al. Bioorg Med Chem. 2008 Jun 1;16(11):5982-98. doi: 10.1016/j.bmc.2008.04.058. Epub 2008 Apr 26. Bioorg Med Chem. 2008. PMID: 18490167

6

Search for influence of spatial properties on affinity at α1-adrenoceptor subtypes for phenylpiperazine derivatives of phenytoin.

Handzlik J, Pertz HH, Görnemann T, Jähnichen S, Kieć-Kononowicz K. Handzlik J, et al. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6152-6. doi: 10.1016/j.bmcl.2010.07.101. Epub 2010 Jul 30. Bioorg Med Chem Lett. 2010. PMID: 20813529

7

Pharmacophore models based studies on the affinity and selectivity toward 5-HT1A with reference to α1-adrenergic receptors among arylpiperazine derivatives of phenytoin.

Handzlik J, Szymańska E, Nędza K, Kubacka M, Siwek A, Mogilski S, Handzlik J, Filipek B, Kieć-Kononowicz K. Handzlik J, et al. Bioorg Med Chem. 2011 Feb 1;19(3):1349-60. doi: 10.1016/j.bmc.2010.11.051. Epub 2010 Dec 5. Bioorg Med Chem. 2011. PMID: 21232965

8

N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands.

Więcek M, Kottke T, Ligneau X, Schunack W, Seifert R, Stark H, Handzlik J, Kieć-Kononowicz K. Więcek M, et al. Among authors: handzlik j. Bioorg Med Chem. 2011 May 1;19(9):2850-8. doi: 10.1016/j.bmc.2011.03.046. Epub 2011 Mar 24. Bioorg Med Chem. 2011. PMID: 21498080

9

Strategies for bypassing the membrane barrier in multidrug resistant Gram-negative bacteria.

Bolla JM, Alibert-Franco S, Handzlik J, Chevalier J, Mahamoud A, Boyer G, Kieć-Kononowicz K, Pagès JM. Bolla JM, et al. Among authors: handzlik j. FEBS Lett. 2011 Jun 6;585(11):1682-90. doi: 10.1016/j.febslet.2011.04.054. Epub 2011 May 3. FEBS Lett. 2011. PMID: 21549704 Free article. Review.

10

Synthesis and biological activity of tricyclic cycloalkylimidazo-, pyrimido- and diazepinopurinediones.

Drabczyńska A, Yuzlenko O, Köse M, Paskaleva M, Schiedel AC, Karolak-Wojciechowska J, Handzlik J, Karcz T, Kuder K, Müller CE, Kieć-Kononowicz K. Drabczyńska A, et al. Among authors: handzlik j. Eur J Med Chem. 2011 Sep;46(9):3590-607. doi: 10.1016/j.ejmech.2011.05.023. Epub 2011 May 23. Eur J Med Chem. 2011. PMID: 21664729

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