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The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia.
Ham DJ, Börsch A, Lin S, Thürkauf M, Weihrauch M, Reinhard JR, Delezie J, Battilana F, Wang X, Kaiser MS, Guridi M, Sinnreich M, Rich MM, Mittal N, Tintignac LA, Handschin C, Zavolan M, Rüegg MA. Ham DJ, et al. Among authors: handschin c. Nat Commun. 2020 Sep 9;11(1):4510. doi: 10.1038/s41467-020-18140-1. Nat Commun. 2020. PMID: 32908143 Free PMC article.
Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function.
Romanino K, Mazelin L, Albert V, Conjard-Duplany A, Lin S, Bentzinger CF, Handschin C, Puigserver P, Zorzato F, Schaeffer L, Gangloff YG, Rüegg MA. Romanino K, et al. Among authors: handschin c. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20808-13. doi: 10.1073/pnas.1111448109. Epub 2011 Dec 5. Proc Natl Acad Sci U S A. 2011. PMID: 22143799 Free PMC article.
Endocrine Crosstalk Between Skeletal Muscle and the Brain.
Delezie J, Handschin C. Delezie J, et al. Among authors: handschin c. Front Neurol. 2018 Aug 24;9:698. doi: 10.3389/fneur.2018.00698. eCollection 2018. Front Neurol. 2018. PMID: 30197620 Free PMC article. Review.
Peroxisome proliferator-activated receptor γ coactivator 1α regulates mitochondrial calcium homeostasis, sarcoplasmic reticulum stress, and cell death to mitigate skeletal muscle aging.
Gill JF, Delezie J, Santos G, McGuirk S, Schnyder S, Frank S, Rausch M, St-Pierre J, Handschin C. Gill JF, et al. Among authors: handschin c. Aging Cell. 2019 Oct;18(5):e12993. doi: 10.1111/acel.12993. Epub 2019 Jul 10. Aging Cell. 2019. PMID: 31290266 Free PMC article.
BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle.
Delezie J, Weihrauch M, Maier G, Tejero R, Ham DJ, Gill JF, Karrer-Cardel B, Rüegg MA, Tabares L, Handschin C. Delezie J, et al. Among authors: handschin c. Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):16111-16120. doi: 10.1073/pnas.1900544116. Epub 2019 Jul 18. Proc Natl Acad Sci U S A. 2019. PMID: 31320589 Free PMC article.
154 results