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Long-read genome sequencing and variant reanalysis increase diagnostic yield in neurodevelopmental disorders.
Hiatt SM, Lawlor JMJ, Handley LH, Latner DR, Bonnstetter ZT, Finnila CR, Thompson ML, Boston LB, Williams M, Nunez IR, Jenkins J, Kelley WV, Bebin EM, Lopez MA, Hurst ACE, Korf BR, Schmutz J, Grimwood J, Cooper GM. Hiatt SM, et al. Among authors: handley lh. medRxiv [Preprint]. 2024 Mar 26:2024.03.22.24304633. doi: 10.1101/2024.03.22.24304633. medRxiv. 2024. PMID: 38585854 Free PMC article. Preprint.
A three-arm randomised phase II study of the MEK inhibitor selumetinib alone or in combination with paclitaxel in metastatic uveal melanoma.
Sacco JJ, Jackson R, Corrie P, Danson S, Evans TRJ, Ochsenreither S, Kumar S, Goodman A, Larkin J, Karydis I, Steven N, Lorigan P, Plummer R, Patel P, Psarelli E, Olsson-Brown A, Shaw H, Leyvraz S, Handley L, Rawcliffe C, Nathan P. Sacco JJ, et al. Among authors: handley l. Eur J Cancer. 2024 May;202:114009. doi: 10.1016/j.ejca.2024.114009. Epub 2024 Mar 11. Eur J Cancer. 2024. PMID: 38547774 Free article. Clinical Trial.
Biosynthesis of Haloterpenoids in Red Algae via Microbial-like Type I Terpene Synthases.
Steele TS, Burkhardt I, Moore ML, de Rond T, Bone HK, Barry K, Bunting VM, Grimwood J, Handley LH, Rajasekar S, Talag J, Michael TP, Moore BS. Steele TS, et al. Among authors: handley lh. ACS Chem Biol. 2024 Jan 19;19(1):185-192. doi: 10.1021/acschembio.3c00627. Epub 2023 Dec 11. ACS Chem Biol. 2024. PMID: 38081799 Free PMC article.
Convergent evolution and horizontal gene transfer in Arctic Ocean microalgae.
Dorrell RG, Kuo A, Füssy Z, Richardson EH, Salamov A, Zarevski N, Freyria NJ, Ibarbalz FM, Jenkins J, Pierella Karlusich JJ, Stecca Steindorff A, Edgar RE, Handley L, Lail K, Lipzen A, Lombard V, McFarlane J, Nef C, Novák Vanclová AM, Peng Y, Plott C, Potvin M, Vieira FRJ, Barry K, de Vargas C, Henrissat B, Pelletier E, Schmutz J, Wincker P, Dacks JB, Bowler C, Grigoriev IV, Lovejoy C. Dorrell RG, et al. Among authors: handley l. Life Sci Alliance. 2022 Dec 15;6(3):e202201833. doi: 10.26508/lsa.202201833. Print 2023 Mar. Life Sci Alliance. 2022. PMID: 36522135 Free PMC article.
A generalist-specialist trade-off between switchgrass cytotypes impacts climate adaptation and geographic range.
Napier JD, Grabowski PP, Lovell JT, Bonnette J, Mamidi S, Gomez-Hughes MJ, VanWallendael A, Weng X, Handley LH, Kim MK, Boe AR, Fay PA, Fritschi FB, Jastrow JD, Lloyd-Reilley J, Lowry DB, Matamala R, Mitchell RB, Rouquette FM Jr, Wu Y, Webber J, Jones T, Barry K, Grimwood J, Schmutz J, Juenger TE. Napier JD, et al. Among authors: handley lh. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2118879119. doi: 10.1073/pnas.2118879119. Epub 2022 Apr 4. Proc Natl Acad Sci U S A. 2022. PMID: 35377798 Free PMC article.
Long-read genome sequencing for the molecular diagnosis of neurodevelopmental disorders.
Hiatt SM, Lawlor JMJ, Handley LH, Ramaker RC, Rogers BB, Partridge EC, Boston LB, Williams M, Plott CB, Jenkins J, Gray DE, Holt JM, Bowling KM, Bebin EM, Grimwood J, Schmutz J, Cooper GM. Hiatt SM, et al. Among authors: handley lh. HGG Adv. 2021 Apr 8;2(2):100023. doi: 10.1016/j.xhgg.2021.100023. Epub 2021 Jan 16. HGG Adv. 2021. PMID: 33937879 Free PMC article.
IgG4-related disease: Association with a rare gene variant expressed in cytotoxic T cells.
Newman JH, Shaver A, Sheehan JH, Mallal S, Stone JH, Pillai S, Bastarache L, Riebau D, Allard-Chamard H, Stone WM, Perugino C, Pilkinton M, Smith SA, McDonnell WJ, Capra JA, Meiler J, Cogan J, Xing K, Mahajan VS, Mattoo H, Hamid R, Phillips JA 3rd; Undiagnosed Disease Network. Newman JH, et al. Mol Genet Genomic Med. 2019 Jun;7(6):e686. doi: 10.1002/mgg3.686. Epub 2019 Apr 16. Mol Genet Genomic Med. 2019. PMID: 30993913 Free PMC article.
79 results