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A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties.
Kupchinsky S, Centioni S, Howard T, Trzupek J, Roller S, Carnahan V, Townes H, Purnell B, Price C, Handl H, Summerville K, Johnson K, Toth J, Hudson S, Kiakos K, Hartley JA, Lee M. Kupchinsky S, et al. Among authors: handl h. Bioorg Med Chem. 2004 Dec 1;12(23):6221-36. doi: 10.1016/j.bmc.2004.08.051. Bioorg Med Chem. 2004. PMID: 15519165
Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-cyclopropylfurano[2,3-e]indoline (seco-iso-CFI) and seco-cyclopropyltetrahydrofurano[2,3-f]quinoline (seco-CFQ) analogues.
Howard TT, Lingerfelt BM, Purnell BL, Scott AE, Price CA, Townes HM, McNulty L, Handl HL, Summerville K, Hudson SJ, Bowen JP, Kiakos K, Hartley JA, Lee M. Howard TT, et al. Bioorg Med Chem. 2002 Sep;10(9):2941-52. doi: 10.1016/s0968-0896(02)00157-8. Bioorg Med Chem. 2002. PMID: 12110316
Hitting multiple targets with multimeric ligands.
Handl HL, Vagner J, Han H, Mash E, Hruby VJ, Gillies RJ. Handl HL, et al. Expert Opin Ther Targets. 2004 Dec;8(6):565-86. doi: 10.1517/14728222.8.6.565. Expert Opin Ther Targets. 2004. PMID: 15584863 Review.
Rigid linkers for bioactive peptides.
Vagner J, Handl HL, Monguchi Y, Jana U, Begay LJ, Mash EA, Hruby VJ, Gillies RJ. Vagner J, et al. Bioconjug Chem. 2006 Nov-Dec;17(6):1545-50. doi: 10.1021/bc060154p. Bioconjug Chem. 2006. PMID: 17105235 Free PMC article.
22 results