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Page 1
Chemically modified hCFTR mRNAs recuperate lung function in a mouse model of cystic fibrosis.
Haque AKMA, Dewerth A, Antony JS, Riethmüller J, Schweizer GR, Weinmann P, Latifi N, Yasar H, Pedemonte N, Sondo E, Weidensee B, Ralhan A, Laval J, Schlegel P, Seitz C, Loretz B, Lehr CM, Handgretinger R, Kormann MSD. Haque AKMA, et al. Among authors: handgretinger r. Sci Rep. 2018 Nov 13;8(1):16776. doi: 10.1038/s41598-018-34960-0. Sci Rep. 2018. PMID: 30425265 Free PMC article.
Expression of therapeutic proteins after delivery of chemically modified mRNA in mice.
Kormann MS, Hasenpusch G, Aneja MK, Nica G, Flemmer AW, Herber-Jonat S, Huppmann M, Mays LE, Illenyi M, Schams A, Griese M, Bittmann I, Handgretinger R, Hartl D, Rosenecker J, Rudolph C. Kormann MS, et al. Among authors: handgretinger r. Nat Biotechnol. 2011 Feb;29(2):154-7. doi: 10.1038/nbt.1733. Epub 2011 Jan 9. Nat Biotechnol. 2011. PMID: 21217696
Long-term IL-2 therapy after transplantation of T cell depleted stem cells from alternative donors in children.
Schlegel P, Teltschik HM, Pfeiffer M, Handgretinger R, Schumm M, Koscielniak E, Feuchtinger T, Klingebiel T, Bader P, Schlegel PG, Greil J, Lang P. Schlegel P, et al. Among authors: handgretinger r. Best Pract Res Clin Haematol. 2011 Sep;24(3):443-52. doi: 10.1016/j.beha.2011.04.007. Epub 2011 Jun 25. Best Pract Res Clin Haematol. 2011. PMID: 21925097
Flagellin induces myeloid-derived suppressor cells: implications for Pseudomonas aeruginosa infection in cystic fibrosis lung disease.
Rieber N, Brand A, Hector A, Graepler-Mainka U, Ost M, Schäfer I, Wecker I, Neri D, Wirth A, Mays L, Zundel S, Fuchs J, Handgretinger R, Stern M, Hogardt M, Döring G, Riethmüller J, Kormann M, Hartl D. Rieber N, et al. Among authors: handgretinger r. J Immunol. 2013 Feb 1;190(3):1276-84. doi: 10.4049/jimmunol.1202144. Epub 2012 Dec 31. J Immunol. 2013. PMID: 23277486
Modified Foxp3 mRNA protects against asthma through an IL-10-dependent mechanism.
Mays LE, Ammon-Treiber S, Mothes B, Alkhaled M, Rottenberger J, Müller-Hermelink ES, Grimm M, Mezger M, Beer-Hammer S, von Stebut E, Rieber N, Nürnberg B, Schwab M, Handgretinger R, Idzko M, Hartl D, Kormann MS. Mays LE, et al. Among authors: handgretinger r. J Clin Invest. 2013 Mar;123(3):1216-28. doi: 10.1172/JCI65351. Epub 2013 Feb 8. J Clin Invest. 2013. PMID: 23391720 Free PMC article.
Pediatric posttransplant relapsed/refractory B-precursor acute lymphoblastic leukemia shows durable remission by therapy with the T-cell engaging bispecific antibody blinatumomab.
Schlegel P, Lang P, Zugmaier G, Ebinger M, Kreyenberg H, Witte KE, Feucht J, Pfeiffer M, Teltschik HM, Kyzirakos C, Feuchtinger T, Handgretinger R. Schlegel P, et al. Among authors: handgretinger r. Haematologica. 2014 Jul;99(7):1212-9. doi: 10.3324/haematol.2013.100073. Epub 2014 Apr 11. Haematologica. 2014. PMID: 24727818 Free PMC article.
In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency.
Mahiny AJ, Dewerth A, Mays LE, Alkhaled M, Mothes B, Malaeksefat E, Loretz B, Rottenberger J, Brosch DM, Reautschnig P, Surapolchai P, Zeyer F, Schams A, Carevic M, Bakele M, Griese M, Schwab M, Nürnberg B, Beer-Hammer S, Handgretinger R, Hartl D, Lehr CM, Kormann MS. Mahiny AJ, et al. Among authors: handgretinger r. Nat Biotechnol. 2015 Jun;33(6):584-6. doi: 10.1038/nbt.3241. Epub 2015 May 18. Nat Biotechnol. 2015. PMID: 25985262 No abstract available.
544 results