Handa H - Search Results

1

LRRK2 is involved in the chemotaxis of neutrophils and differentiated HL-60 cells, and the inhibition of LRRK2 kinase activity increases fMLP-induced chemotactic activity.

Mazaki Y, Handa H, Fumoto Y, Horinouchi T, Onodera Y. Mazaki Y, et al. Among authors: handa h. Cell Commun Signal. 2023 Oct 30;21(1):300. doi: 10.1186/s12964-023-01305-y. Cell Commun Signal. 2023. PMID: 37904222 Free PMC article.

2

Co-overexpression of GEP100 and AMAP1 proteins correlates with rapid local recurrence after breast conservative therapy.

Kinoshita R, Nam JM, Ito YM, Hatanaka KC, Hashimoto A, Handa H, Otsuka Y, Hashimoto S, Onodera Y, Hosoda M, Onodera S, Shimizu S, Tanaka S, Shirato H, Tanino M, Sabe H. Kinoshita R, et al. Among authors: handa h. PLoS One. 2013 Oct 7;8(10):e76791. doi: 10.1371/journal.pone.0076791. eCollection 2013. PLoS One. 2013. PMID: 24116160 Free PMC article.

3

Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer.

Hashimoto S, Mikami S, Sugino H, Yoshikawa A, Hashimoto A, Onodera Y, Furukawa S, Handa H, Oikawa T, Okada Y, Oya M, Sabe H. Hashimoto S, et al. Among authors: handa h. Nat Commun. 2016 Feb 8;7:10656. doi: 10.1038/ncomms10656. Nat Commun. 2016. PMID: 26854204 Free PMC article.

4

P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance.

Hashimoto A, Oikawa T, Hashimoto S, Sugino H, Yoshikawa A, Otsuka Y, Handa H, Onodera Y, Nam JM, Oneyama C, Okada M, Fukuda M, Sabe H. Hashimoto A, et al. Among authors: handa h. J Cell Biol. 2016 Apr 11;213(1):81-95. doi: 10.1083/jcb.201510002. Epub 2016 Apr 4. J Cell Biol. 2016. PMID: 27044891 Free PMC article.

5

ZEB1 induces EPB41L5 in the cancer mesenchymal program that drives ARF6-based invasion, metastasis and drug resistance.

Hashimoto A, Hashimoto S, Sugino H, Yoshikawa A, Onodera Y, Handa H, Oikawa T, Sabe H. Hashimoto A, et al. Among authors: handa h. Oncogenesis. 2016 Sep 12;5(9):e259. doi: 10.1038/oncsis.2016.60. Oncogenesis. 2016. PMID: 27617643 Free PMC article.

6

Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model.

Otsuka Y, Oikawa T, Yoshino H, Hashimoto S, Handa H, Yamamoto H, Hashimoto A, Sabe H. Otsuka Y, et al. Among authors: handa h. Cell Commun Signal. 2018 Jan 5;16(1):1. doi: 10.1186/s12964-017-0212-z. Cell Commun Signal. 2018. PMID: 29329590 Free PMC article.

7

Necessity of p53-binding to the CDH1 locus for its expression defines two epithelial cell types differing in their integrity.

Oikawa T, Otsuka Y, Onodera Y, Horikawa M, Handa H, Hashimoto S, Suzuki Y, Sabe H. Oikawa T, et al. Among authors: handa h. Sci Rep. 2018 Jan 25;8(1):1595. doi: 10.1038/s41598-018-20043-7. Sci Rep. 2018. PMID: 29371630 Free PMC article.

8

Epithelial-specific histone modification of the miR-96/182 locus targeting AMAP1 mRNA predisposes p53 to suppress cell invasion in epithelial cells.

Handa H, Hashimoto A, Hashimoto S, Sugino H, Oikawa T, Sabe H. Handa H, et al. Cell Commun Signal. 2018 Dec 4;16(1):94. doi: 10.1186/s12964-018-0302-6. Cell Commun Signal. 2018. PMID: 30509302 Free PMC article.

9

ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer.

Hashimoto S, Furukawa S, Hashimoto A, Tsutaho A, Fukao A, Sakamura Y, Parajuli G, Onodera Y, Otsuka Y, Handa H, Oikawa T, Hata S, Nishikawa Y, Mizukami Y, Kodama Y, Murakami M, Fujiwara T, Hirano S, Sabe H. Hashimoto S, et al. Among authors: handa h. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17450-17459. doi: 10.1073/pnas.1901765116. Epub 2019 Aug 9. Proc Natl Acad Sci U S A. 2019. PMID: 31399545 Free PMC article.

10

Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure.

Furihata T, Takada S, Kakutani N, Maekawa S, Tsuda M, Matsumoto J, Mizushima W, Fukushima A, Yokota T, Enzan N, Matsushima S, Handa H, Fumoto Y, Nio-Kobayashi J, Iwanaga T, Tanaka S, Tsutsui H, Sabe H, Kinugawa S. Furihata T, et al. Among authors: handa h. Commun Biol. 2021 Jan 29;4(1):138. doi: 10.1038/s42003-021-01675-4. Commun Biol. 2021. PMID: 33514783 Free PMC article.

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