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Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma.
Haertle L, Barrio S, Munawar U, Han S, Zhou X, Simicek M, Vogt C, Truger M, Fernandez RA, Steinhardt M, Weingart J, Snaurova R, Nerreter S, Teufel E, Garitano-Trojaola A, Da Viá M, Ruiz-Heredia Y, Rosenwald A, Bolli N, Hajek R, Raab P, Raab MS, Weinhold N, Haferlach C, Haaf T, Martinez-Lopez J, Einsele H, Rasche L, Kortüm KM. Haertle L, et al. Among authors: han s. Clin Cancer Res. 2023 Jan 4;29(1):279-288. doi: 10.1158/1078-0432.CCR-22-1161. Clin Cancer Res. 2023. PMID: 36282272
Cereblon enhancer methylation and IMiD resistance in multiple myeloma.
Haertle L, Barrio S, Munawar U, Han S, Zhou X, Vogt C, Fernández RA, Bittrich M, Ruiz-Heredia Y, Da Viá M, Zovko J, Garitano-Trojaola A, Bolli N, Ruckdeschel A, Stühmer T, Chatterjee M, Kull M, Krönke J, Agirre X, Martin-Subero JI, Raab P, Einsele H, Rasche L, Martinez-Lopez J, Haaf T, Kortüm KM. Haertle L, et al. Among authors: han s. Blood. 2021 Nov 4;138(18):1721-1726. doi: 10.1182/blood.2020010452. Blood. 2021. PMID: 34115836 Free PMC article.
Genetic Alterations in Members of the Proteasome 26S Subunit, AAA-ATPase (PSMC) Gene Family in the Light of Proteasome Inhibitor Resistance in Multiple Myeloma.
Haertle L, Buenache N, Cuesta Hernández HN, Simicek M, Snaurova R, Rapado I, Martinez N, López-Muñoz N, Sánchez-Pina JM, Munawar U, Han S, Ruiz-Heredia Y, Colmenares R, Gallardo M, Sanchez-Beato M, Piris MA, Samur MK, Munshi NC, Ayala R, Kortüm KM, Barrio S, Martínez-López J. Haertle L, et al. Among authors: han s. Cancers (Basel). 2023 Jan 15;15(2):532. doi: 10.3390/cancers15020532. Cancers (Basel). 2023. PMID: 36672481 Free PMC article.
High-dose carfilzomib achieves superior anti-tumor activity over low-dose and recaptures response in relapsed/refractory multiple myeloma resistant to lowdose carfilzomib by co-inhibiting the β2 and β1 subunits of the proteasome complex.
Zhou X, Besse A, Peter J, Steinhardt MJ, Vogt C, Nerreter S, Teufel E, Stanojkovska E, Xiao X, Hornburger H, Haertle L, Lopez MM, Munawar U, Riedel A, Han S, Maurits E, Overkleeft HS, Florea B, Einsele H, Kortüm KM, Driessen C, Besse L, Rasche L. Zhou X, et al. Among authors: han s. Haematologica. 2023 Jun 1;108(6):1628-1639. doi: 10.3324/haematol.2022.282225. Haematologica. 2023. PMID: 36727403 Free PMC article.
Bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1.
Zhou X, Han S, Cebulla N, Haertle L, Steinhardt MJ, Schirmer D, Runau E, Flamm L, Terhorst C, Jähnel L, Vogt C, Nerreter S, Teufel E, Stanojkovska E, Mersi J, Munawar U, Schindehütte M, Blum R, Reinhold AK, Scherf-Clavel O, Rittner HL, Pham M, Rasche L, Einsele H, Sommer C, Kortüm KM. Zhou X, et al. Among authors: han s. Biomark Res. 2023 May 16;11(1):52. doi: 10.1186/s40364-023-00490-9. Biomark Res. 2023. PMID: 37194045 Free PMC article.
Impaired FADD/BID signaling mediates cross-resistance to immunotherapy in Multiple Myeloma.
Munawar U, Zhou X, Prommersberger S, Nerreter S, Vogt C, Steinhardt MJ, Truger M, Mersi J, Teufel E, Han S, Haertle L, Banholzer N, Eiring P, Danhof S, Navarro-Aguadero MA, Fernandez-Martin A, Ortiz-Ruiz A, Barrio S, Gallardo M, Valeri A, Castellano E, Raab P, Rudert M, Haferlach C, Sauer M, Hudecek M, Martinez-Lopez J, Waldschmidt J, Einsele H, Rasche L, Kortüm KM. Munawar U, et al. Among authors: han s. Commun Biol. 2023 Dec 21;6(1):1299. doi: 10.1038/s42003-023-05683-4. Commun Biol. 2023. PMID: 38129580 Free PMC article.
Soluble B-cell maturation antigen in lacrimal fluid as a potential biomarker and mediator of keratopathy in multiple myeloma.
Munawar U, Theuersbacher J, Steinhardt MJ, Zhou X, Han S, Nerreter S, Vogt C, Kurian S, Keller T, Regensburger AK, Teufel E, Mersi J, Bittrich M, Seifert F, Haider MS, Rasche L, Hillenkamp J, Einsele H, Kampik D, Kortüm KM, Waldschmidt JM. Munawar U, et al. Among authors: han s. Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2024.285205. Online ahead of print. Haematologica. 2024. PMID: 38572568 Free article.
Unraveling the genetic complexities of combined retinal dystrophy and hearing impairment.
Bahena P, Daftarian N, Maroofian R, Linares P, Villalobos D, Mirrahimi M, Rad A, Doll J, Hofrichter MAH, Koparir A, Röder T, Han S, Sabbaghi H, Ahmadieh H, Behboudi H, Villanueva-Mendoza C, Cortés-Gonzalez V, Zamora-Ortiz R, Kohl S, Kuehlewein L, Darvish H, Alehabib E, Arenas-Sordo ML, Suri F, Vona B, Haaf T. Bahena P, et al. Among authors: han s. Hum Genet. 2022 Apr;141(3-4):785-803. doi: 10.1007/s00439-021-02303-1. Epub 2021 Jun 20. Hum Genet. 2022. PMID: 34148116 Free PMC article.
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