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Impact of the KCNQ2/3 Channel Opener Ezogabine on Reward Circuit Activity and Clinical Symptoms in Depression: Results From a Randomized Controlled Trial.
Costi S, Morris LS, Kirkwood KA, Hoch M, Corniquel M, Vo-Le B, Iqbal T, Chadha N, Pizzagalli DA, Whitton A, Bevilacqua L, Jha MK, Ursu S, Swann AC, Collins KA, Salas R, Bagiella E, Parides MK, Stern ER, Iosifescu DV, Han MH, Mathew SJ, Murrough JW. Costi S, et al. Among authors: han mh. Am J Psychiatry. 2021 May 1;178(5):437-446. doi: 10.1176/appi.ajp.2020.20050653. Epub 2021 Mar 3. Am J Psychiatry. 2021. PMID: 33653118 Free PMC article. Clinical Trial.
Neurobiology of resilience.
Russo SJ, Murrough JW, Han MH, Charney DS, Nestler EJ. Russo SJ, et al. Among authors: han mh. Nat Neurosci. 2012 Nov;15(11):1475-84. doi: 10.1038/nn.3234. Epub 2012 Oct 14. Nat Neurosci. 2012. PMID: 23064380 Free PMC article. Review.
KCNQ channel openers reverse depressive symptoms via an active resilience mechanism.
Friedman AK, Juarez B, Ku SM, Zhang H, Calizo RC, Walsh JJ, Chaudhury D, Zhang S, Hawkins A, Dietz DM, Murrough JW, Ribadeneira M, Wong EH, Neve RL, Han MH. Friedman AK, et al. Among authors: han mh. Nat Commun. 2016 May 24;7:11671. doi: 10.1038/ncomms11671. Nat Commun. 2016. PMID: 27216573 Free PMC article.
Effects of the KCNQ channel opener ezogabine on functional connectivity of the ventral striatum and clinical symptoms in patients with major depressive disorder.
Tan A, Costi S, Morris LS, Van Dam NT, Kautz M, Whitton AE, Friedman AK, Collins KA, Ahle G, Chadha N, Do B, Pizzagalli DA, Iosifescu DV, Nestler EJ, Han MH, Murrough JW. Tan A, et al. Among authors: han mh. Mol Psychiatry. 2020 Jun;25(6):1323-1333. doi: 10.1038/s41380-018-0283-2. Epub 2018 Nov 1. Mol Psychiatry. 2020. PMID: 30385872 Free PMC article. Clinical Trial.
Neurobiology of Resilience: Interface Between Mind and Body.
Cathomas F, Murrough JW, Nestler EJ, Han MH, Russo SJ. Cathomas F, et al. Among authors: han mh. Biol Psychiatry. 2019 Sep 15;86(6):410-420. doi: 10.1016/j.biopsych.2019.04.011. Epub 2019 Apr 17. Biol Psychiatry. 2019. PMID: 31178098 Free PMC article. Review.
Brain-Derived Neurotrophic Factor in the Mesolimbic Reward Circuitry Mediates Nociception in Chronic Neuropathic Pain.
Zhang H, Qian YL, Li C, Liu D, Wang L, Wang XY, Liu MJ, Liu H, Zhang S, Guo XY, Yang JX, Ding HL, Koo JW, Mouzon E, Deisseroth K, Nestler EJ, Zachariou V, Han MH, Cao JL. Zhang H, et al. Among authors: han mh. Biol Psychiatry. 2017 Oct 15;82(8):608-618. doi: 10.1016/j.biopsych.2017.02.1180. Epub 2017 Mar 1. Biol Psychiatry. 2017. PMID: 28390647 Free PMC article.
HCN Channel Targets for Novel Antidepressant Treatment.
Ku SM, Han MH. Ku SM, et al. Among authors: han mh. Neurotherapeutics. 2017 Jul;14(3):698-715. doi: 10.1007/s13311-017-0538-7. Neurotherapeutics. 2017. PMID: 28560710 Free PMC article. Review.
Role of Mesolimbic Brain-Derived Neurotrophic Factor in Depression.
Koo JW, Chaudhury D, Han MH, Nestler EJ. Koo JW, et al. Among authors: han mh. Biol Psychiatry. 2019 Nov 15;86(10):738-748. doi: 10.1016/j.biopsych.2019.05.020. Epub 2019 Jun 4. Biol Psychiatry. 2019. PMID: 31327473 Free PMC article. Review.
The Resilient Phenotype Induced by Prophylactic Ketamine Exposure During Adolescence Is Mediated by the Ventral Tegmental Area-Nucleus Accumbens Pathway.
Parise EM, Parise LF, Sial OK, Cardona-Acosta AM, Gyles TM, Juarez B, Chaudhury D, Han MH, Nestler EJ, Bolaños-Guzmán CA. Parise EM, et al. Among authors: han mh. Biol Psychiatry. 2021 Oct 1;90(7):482-493. doi: 10.1016/j.biopsych.2021.05.002. Epub 2021 May 8. Biol Psychiatry. 2021. PMID: 34247781 Free PMC article.
849 results