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A live attenuated virus-based intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2.
Chen J, Wang P, Yuan L, Zhang L, Zhang L, Zhao H, Chen C, Wang X, Han J, Chen Y, Jia J, Lu Z, Hong J, Lu Z, Wang Q, Chen R, Qi R, Ma J, Zhou M, Yu H, Zhuang C, Liu X, Han Q, Wang G, Su Y, Yuan Q, Cheng T, Wu T, Ye X, Zhang T, Li C, Zhang J, Zhu H, Chen Y, Chen H, Xia N. Chen J, et al. Among authors: han q, han j. Sci Bull (Beijing). 2022 Jul 15;67(13):1372-1387. doi: 10.1016/j.scib.2022.05.018. Epub 2022 May 26. Sci Bull (Beijing). 2022. PMID: 35637645 Free PMC article.
Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16.
He M, Xu L, Zheng Q, Zhu R, Yin Z, Zha Z, Lin Y, Yang L, Huang Y, Ye X, Li S, Hou W, Wu Y, Han J, Liu D, Li Z, Chen Z, Yu H, Que Y, Wang Y, Yan X, Zhang J, Gu Y, Zhou ZH, Cheng T, Li S, Xia N. He M, et al. Among authors: han j. Cell Host Microbe. 2020 Feb 12;27(2):249-261.e5. doi: 10.1016/j.chom.2020.01.003. Epub 2020 Feb 5. Cell Host Microbe. 2020. PMID: 32027857 Free PMC article.
Near-atomic cryo-electron microscopy structures of varicella-zoster virus capsids.
Wang W, Zheng Q, Pan D, Yu H, Fu W, Liu J, He M, Zhu R, Cai Y, Huang Y, Zha Z, Chen Z, Ye X, Han J, Que Y, Wu T, Zhang J, Li S, Zhu H, Zhou ZH, Cheng T, Xia N. Wang W, et al. Among authors: han j. Nat Microbiol. 2020 Dec;5(12):1542-1552. doi: 10.1038/s41564-020-0785-y. Epub 2020 Sep 7. Nat Microbiol. 2020. PMID: 32895526 Free PMC article.
Cryo-EM structures reveal the molecular basis of receptor-initiated coxsackievirus uncoating.
Xu L, Zheng Q, Zhu R, Yin Z, Yu H, Lin Y, Wu Y, He M, Huang Y, Jiang Y, Sun H, Zha Z, Yang H, Huang Q, Zhang D, Chen Z, Ye X, Han J, Yang L, Liu C, Que Y, Fang M, Gu Y, Zhang J, Luo W, Zhou ZH, Li S, Cheng T, Xia N. Xu L, et al. Among authors: han j. Cell Host Microbe. 2021 Mar 10;29(3):448-462.e5. doi: 10.1016/j.chom.2021.01.001. Epub 2021 Feb 3. Cell Host Microbe. 2021. PMID: 33539764 Free PMC article.
Development of a skin- and neuro-attenuated live vaccine for varicella.
Wang W, Pan D, Fu W, Ye X, Han J, Yang L, Jia J, Liu J, Zhu R, Zhang Y, Liu C, Ye J, Selariu A, Que Y, Zhao Q, Wu T, Li Y, Zhang J, Cheng T, Zhu H, Xia N. Wang W, et al. Among authors: han j. Nat Commun. 2022 Feb 11;13(1):824. doi: 10.1038/s41467-022-28329-1. Nat Commun. 2022. PMID: 35149692 Free PMC article.
Safety and immunogenicity of a live-attenuated influenza virus vector-based intranasal SARS-CoV-2 vaccine in adults: randomised, double-blind, placebo-controlled, phase 1 and 2 trials.
Zhu F, Zhuang C, Chu K, Zhang L, Zhao H, Huang S, Su Y, Lin H, Yang C, Jiang H, Zang X, Liu D, Pan H, Hu Y, Liu X, Chen Q, Song Q, Quan J, Huang Z, Zhong G, Chen J, Han J, Sun H, Cui L, Li J, Chen Y, Zhang T, Ye X, Li C, Wu T, Zhang J, Xia NS. Zhu F, et al. Among authors: han j. Lancet Respir Med. 2022 Aug;10(8):749-760. doi: 10.1016/S2213-2600(22)00131-X. Epub 2022 May 26. Lancet Respir Med. 2022. PMID: 35644168 Free PMC article. Clinical Trial.
Oncolytic virus expressing PD-1 inhibitors activates a collaborative intratumoral immune response to control tumor and synergizes with CTLA-4 or TIM-3 blockade.
Ju F, Luo Y, Lin C, Jia X, Xu Z, Tian R, Lin Y, Zhao M, Chang Y, Huang X, Li S, Ren W, Qin Y, Yu M, Jia J, Han J, Luo W, Zhang J, Fu G, Ye X, Huang C, Xia N. Ju F, et al. Among authors: han j. J Immunother Cancer. 2022 Jun;10(6):e004762. doi: 10.1136/jitc-2022-004762. J Immunother Cancer. 2022. PMID: 35688558 Free PMC article.
Safety and immunogenicity of a skin- and neuro-attenuated live vaccine for varicella: a randomized, double-blind, controlled, dose-escalation and age de-escalation phase 1 clinical trial.
Mo ZJ, Huang SJ, Qiu LX, Li CG, Yu XJ, Li MQ, Chen Z, Zhong GH, Pan DQ, Huang LR, Lv BJ, Cui XL, Song QQ, Jia JZ, Han JL, Wang W, Zhu H, Cheng T, Su YY, Li YM, Ye XZ, Wu T, Zhang J, Xia NS. Mo ZJ, et al. Among authors: han jl. Lancet Reg Health West Pac. 2023 Feb 18;34:100707. doi: 10.1016/j.lanwpc.2023.100707. eCollection 2023 May. Lancet Reg Health West Pac. 2023. PMID: 37283962 Free PMC article.
Safety and efficacy of the intranasal spray SARS-CoV-2 vaccine dNS1-RBD: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.
Zhu F, Huang S, Liu X, Chen Q, Zhuang C, Zhao H, Han J, Jaen AM, Do TH, Peter JG, Dorado AG, Tirador LS, Zabat GMA, Villalobos REM, Gueco GP, Botha LLG, Iglesias Pertuz SP, Tan J, Zhu K, Quan J, Lin H, Huang Y, Jia J, Chu X, Chen J, Chen Y, Zhang T, Su Y, Li C, Ye X, Wu T, Zhang J, Xia N; COVID-19-PRO-003 Study Team. Zhu F, et al. Among authors: han j. Lancet Respir Med. 2023 Dec;11(12):1075-1088. doi: 10.1016/S2213-2600(23)00349-1. Epub 2023 Nov 15. Lancet Respir Med. 2023. PMID: 37979588 Free PMC article. Clinical Trial.
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