Han J - Search Results

1

P300/CBP inhibition sensitizes mantle cell lymphoma to PI3Kδ inhibitor idelalisib.

Zhou XR, Li X, Liao LP, Han J, Huang J, Li JC, Tao HR, Fan SJ, Chen ZF, Li Q, Chen SJ, Ding H, Yang YX, Zhou B, Jiang HL, Chen KX, Zhang YY, Huang CX, Luo C. Zhou XR, et al. Among authors: han j. Acta Pharmacol Sin. 2022 Feb;43(2):457-469. doi: 10.1038/s41401-021-00643-2. Epub 2021 Apr 13. Acta Pharmacol Sin. 2022. PMID: 33850273 Free PMC article.

2

Identification of small molecule inhibitors targeting the SMARCA2 bromodomain from a high-throughput screening assay.

Lu T, Hu JC, Lu WC, Han J, Ding H, Jiang H, Zhang YY, Yue LY, Chen SJ, Jiang HL, Chen KX, Chai HF, Luo C. Lu T, et al. Among authors: han j. Acta Pharmacol Sin. 2018 Sep;39(9):1544-1552. doi: 10.1038/aps.2017.188. Epub 2018 May 24. Acta Pharmacol Sin. 2018. PMID: 29795359 Free PMC article.

3

Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors.

Lu W, Xiong H, Chen Y, Wang C, Zhang H, Xu P, Han J, Xiao S, Ding H, Chen Z, Lu T, Wang J, Zhang Y, Yue L, Liu YC, Zhang C, Yang Y, Jiang H, Chen K, Zhou B, Luo C. Lu W, et al. Among authors: han j. Bioorg Med Chem. 2018 Nov 1;26(20):5397-5407. doi: 10.1016/j.bmc.2018.07.048. Epub 2018 Jul 27. Bioorg Med Chem. 2018. PMID: 30297119

4

Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors.

Yang Y, Zhang R, Li Z, Mei L, Wan S, Ding H, Chen Z, Xing J, Feng H, Han J, Jiang H, Zheng M, Luo C, Zhou B. Yang Y, et al. Among authors: han j. J Med Chem. 2020 Feb 13;63(3):1337-1360. doi: 10.1021/acs.jmedchem.9b01721. Epub 2020 Jan 28. J Med Chem. 2020. PMID: 31910017

5

BRD4 as a therapeutic target for nonfunctioning and growth hormone pituitary adenoma.

Shi C, Ye Z, Han J, Ye X, Lu W, Ji C, Li Z, Ma Z, Zhang Q, Zhang Y, He W, Chen Z, Cao X, Shou X, Zhou X, Wang Y, Zhang Z, Li Y, Ye H, He M, Chen H, Cheng H, Sun J, Cai J, Huang C, Ye F, Luo C, Zhou B, Ding H, Zhao Y. Shi C, et al. Among authors: han j. Neuro Oncol. 2020 Aug 17;22(8):1114-1125. doi: 10.1093/neuonc/noaa084. Neuro Oncol. 2020. PMID: 32246150 Free PMC article.

6

The p300 Inhibitor A-485 Exerts Antitumor Activity in Growth Hormone Pituitary Adenoma.

Ji C, Xu W, Ding H, Chen Z, Shi C, Han J, Yu L, Qiao N, Zhang Y, Cao X, Zhou X, Cheng H, Feng H, Luo C, Li Z, Zhou B, Ye Z, Zhao Y. Ji C, et al. Among authors: han j. J Clin Endocrinol Metab. 2022 May 17;107(6):e2291-e2300. doi: 10.1210/clinem/dgac128. J Clin Endocrinol Metab. 2022. PMID: 35247260 Free PMC article.

7

Discovery of 1,8-acridinedione derivatives as novel GCN5 inhibitors via high throughput screening.

Xiong H, Han J, Wang J, Lu W, Wang C, Chen Y, Fulin Lian, Zhang N, Liu YC, Zhang C, Ding H, Jiang H, Lu W, Luo C, Zhou B. Xiong H, et al. Among authors: han j. Eur J Med Chem. 2018 May 10;151:740-751. doi: 10.1016/j.ejmech.2018.02.005. Epub 2018 Feb 14. Eur J Med Chem. 2018. PMID: 29665527

8

The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening.

Ye X, Zhang R, Lian F, Zhang W, Lu W, Han J, Zhang N, Jin J, Luo C, Chen K, Ye F, Ding H. Ye X, et al. Among authors: han j. Bioorg Med Chem Lett. 2019 Feb 15;29(4):638-645. doi: 10.1016/j.bmcl.2018.12.035. Epub 2018 Dec 17. Bioorg Med Chem Lett. 2019. PMID: 30626558

9

Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening.

Zhang D, Han J, Lu W, Lian F, Wang J, Lu T, Tao H, Xiao S, Zhang F, Liu YC, Liu R, Zhang N, Jiang H, Chen K, Zhao C, Luo C. Zhang D, et al. Among authors: han j. Bioorg Chem. 2019 May;86:494-500. doi: 10.1016/j.bioorg.2019.01.035. Epub 2019 Jan 28. Bioorg Chem. 2019. PMID: 30780018

10

Discovery of novel USP8 inhibitors via Ubiquitin-Rho-110 fluorometric assay based high throughput screening.

Han J, Tian Y, Yu L, Zhang Q, Xu X, Zhang Y, Wang J, Ma Z, Bian J, Luo C, Jiang H, Chen K, Zhao Y, Li Z, Ding H. Han J, et al. Bioorg Chem. 2020 Aug;101:103962. doi: 10.1016/j.bioorg.2020.103962. Epub 2020 May 22. Bioorg Chem. 2020. PMID: 32480171

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