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Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design.
Gimenez LE, Martin C, Yu J, Hollanders C, Hernandez CC, Wu Y, Yao D, Han GW, Dahir NS, Wu L, Van der Poorten O, Lamouroux A, Mannes M, Zhao S, Tourwé D, Stevens RC, Cone RD, Ballet S. Gimenez LE, et al. Among authors: han gw. J Med Chem. 2024 Feb 22;67(4):2690-2711. doi: 10.1021/acs.jmedchem.3c01822. Epub 2024 Feb 12. J Med Chem. 2024. PMID: 38345933
Structural insights into the human niacin receptor HCA2-Gi signalling complex.
Yang Y, Kang HJ, Gao R, Wang J, Han GW, DiBerto JF, Wu L, Tong J, Qu L, Wu Y, Pileski R, Li X, Zhang XC, Zhao S, Kenakin T, Wang Q, Stevens RC, Peng W, Roth BL, Rao Z, Liu ZJ. Yang Y, et al. Among authors: han gw. Nat Commun. 2023 Mar 27;14(1):1692. doi: 10.1038/s41467-023-37177-6. Nat Commun. 2023. PMID: 36973264 Free PMC article.
The activation mechanism and antibody binding mode for orphan GPR20.
Lin X, Jiang S, Wu Y, Wei X, Han GW, Wu L, Liu J, Chen B, Zhang Z, Zhao S, Cherezov V, Xu F. Lin X, et al. Among authors: han gw. Cell Discov. 2023 Feb 28;9(1):23. doi: 10.1038/s41421-023-00520-8. Cell Discov. 2023. PMID: 36849514 Free PMC article.
GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A2A Adenosine Receptor.
Shiriaeva A, Park D, Kim G, Lee Y, Hou X, Jarhad DB, Kim G, Yu J, Hyun YE, Kim W, Gao ZG, Jacobson KA, Han GW, Stevens RC, Jeong LS, Choi S, Cherezov V. Shiriaeva A, et al. Among authors: han gw. J Med Chem. 2022 Sep 8;65(17):11648-11657. doi: 10.1021/acs.jmedchem.2c00462. Epub 2022 Aug 17. J Med Chem. 2022. PMID: 35977382 Free PMC article.
High ligand efficiency quinazoline compounds as novel A2A adenosine receptor antagonists.
Bolteau R, Duroux R, Laversin A, Vreulz B, Shiriaeva A, Stauch B, Han GW, Cherezov V, Renault N, Barczyk A, Ravez S, Coevoet M, Melnyk P, Liberelle M, Yous S. Bolteau R, et al. Among authors: han gw. Eur J Med Chem. 2022 Nov 5;241:114620. doi: 10.1016/j.ejmech.2022.114620. Epub 2022 Jul 22. Eur J Med Chem. 2022. PMID: 35933788
Inhibition of the angiotensin II type 2 receptor AT2R is a novel therapeutic strategy for glioblastoma.
Perryman R, Renziehausen A, Shaye H, Kostagianni AD, Tsiailanis AD, Thorne T, Chatziathanasiadou MV, Sivolapenko GB, El Mubarak MA, Han GW, Zarzycka B, Katritch V, Lebon G, Lo Nigro C, Lattanzio L, Morse SV, Choi JJ, O'Neill K, Kanaki Z, Klinakis A, Crook T, Cherezov V, Tzakos AG, Syed N. Perryman R, et al. Among authors: han gw. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2116289119. doi: 10.1073/pnas.2116289119. Epub 2022 Aug 2. Proc Natl Acad Sci U S A. 2022. PMID: 35917342 Free PMC article.
Publisher Correction: Structural basis of GABA reuptake inhibition.
Motiwala Z, Aduri NG, Shaye H, Han GW, Lam JH, Katritch V, Cherezov V, Gati C. Motiwala Z, et al. Among authors: han gw. Nature. 2022 Aug;608(7921):E15. doi: 10.1038/s41586-022-05080-7. Nature. 2022. PMID: 35840686 No abstract available.
Structural insight into apelin receptor-G protein stoichiometry.
Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault É, Longpré JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F. Yue Y, et al. Among authors: han gw. Nat Struct Mol Biol. 2022 Jul;29(7):688-697. doi: 10.1038/s41594-022-00797-5. Epub 2022 Jul 11. Nat Struct Mol Biol. 2022. PMID: 35817871
189 results