Hammerschmidt SJ - Search Results

1

Peptidyl nitroalkene inhibitors of main protease rationalized by computational and crystallographic investigations as antivirals against SARS-CoV-2.

Medrano FJ, de la Hoz-Rodríguez S, Martí S, Arafet K, Schirmeister T, Hammerschmidt SJ, Müller C, González-Martínez Á, Santillana E, Ziebuhr J, Romero A, Zimmer C, Weldert A, Zimmermann R, Lodola A, Świderek K, Moliner V, González FV. Medrano FJ, et al. Among authors: hammerschmidt sj. Commun Chem. 2024 Jan 18;7(1):15. doi: 10.1038/s42004-024-01104-7. Commun Chem. 2024. PMID: 38238420 Free PMC article.

2

Structure-based lead optimization of peptide-based vinyl methyl ketones as SARS-CoV-2 main protease inhibitors.

Previti S, Ettari R, Calcaterra E, Di Maro S, Hammerschmidt SJ, Müller C, Ziebuhr J, Schirmeister T, Cosconati S, Zappalà M. Previti S, et al. Among authors: hammerschmidt sj. Eur J Med Chem. 2023 Feb 5;247:115021. doi: 10.1016/j.ejmech.2022.115021. Epub 2022 Dec 15. Eur J Med Chem. 2023. PMID: 36549112 Free PMC article.

3

Investigation of the Compatibility between Warheads and Peptidomimetic Sequences of Protease Inhibitors-A Comprehensive Reactivity and Selectivity Study.

Müller P, Meta M, Meidner JL, Schwickert M, Meyr J, Schwickert K, Kersten C, Zimmer C, Hammerschmidt SJ, Frey A, Lahu A, de la Hoz-Rodríguez S, Agost-Beltrán L, Rodríguez S, Diemer K, Neumann W, Gonzàlez FV, Engels B, Schirmeister T. Müller P, et al. Among authors: hammerschmidt sj. Int J Mol Sci. 2023 Apr 13;24(8):7226. doi: 10.3390/ijms24087226. Int J Mol Sci. 2023. PMID: 37108388 Free PMC article.

4

Next Generation of Fluorometric Protease Assays: 7-Nitrobenz-2-oxa-1,3-diazol-4-yl-amides (NBD-Amides) as Class-Spanning Protease Substrates.

Maus H, Müller P, Meta M, Hoba SN, Hammerschmidt SJ, Zimmermann RA, Zimmer C, Fuchs N, Schirmeister T, Barthels F. Maus H, et al. Among authors: hammerschmidt sj. Chemistry. 2023 Sep 6;29(50):e202301855. doi: 10.1002/chem.202301855. Epub 2023 Jul 28. Chemistry. 2023. PMID: 37313627

5

Improving binding entropy by higher ligand symmetry? - A case study with human matriptase.

Hammerschmidt SJ, Maus H, Weldert AC, Gütschow M, Kersten C. Hammerschmidt SJ, et al. RSC Med Chem. 2023 Apr 27;14(5):969-982. doi: 10.1039/d3md00125c. eCollection 2023 May 25. RSC Med Chem. 2023. PMID: 37252099 Free PMC article.

6

A competition smFRET assay to study ligand-induced conformational changes of the dengue virus protease.

Maus H, Hinze G, Hammerschmidt SJ, Basché T, Schirmeister T. Maus H, et al. Among authors: hammerschmidt sj. Protein Sci. 2023 Jan;32(1):e4526. doi: 10.1002/pro.4526. Protein Sci. 2023. PMID: 36461913 Free PMC article.

7

The effects of allosteric and competitive inhibitors on ZIKV protease conformational dynamics explored through smFRET, nanoDSF, DSF, and ¹⁹F NMR.

Maus H, Hammerschmidt SJ, Hinze G, Barthels F, Pérez Carrillo VH, Hellmich UA, Basché T, Schirmeister T. Maus H, et al. Among authors: hammerschmidt sj. Eur J Med Chem. 2023 Oct 5;258:115573. doi: 10.1016/j.ejmech.2023.115573. Epub 2023 Jun 21. Eur J Med Chem. 2023. PMID: 37379675

8

Inhibitory effects of 190 compounds against SARS-CoV-2 M^pr ^o protein: Molecular docking interactions.

Souza GB, Sens L, Hammerschmidt SJ, de Sousa NF, de Carvalho MAG, Dos Santos CVD, Tizziani T, Moreira MA, Pollo LAE, Martin EF, Neto JSS, Biavatti MW, de Assis FF, Ngadjui BT, Simo IK, Ambassa P, Scotti MT, Scotti L, Braga AL, Schirmeister T, Sandjo LP. Souza GB, et al. Among authors: hammerschmidt sj. Arch Pharm (Weinheim). 2023 Aug;356(8):e2300207. doi: 10.1002/ardp.202300207. Epub 2023 May 31. Arch Pharm (Weinheim). 2023. PMID: 37255416

9

Thermodynamic characterization of a macrocyclic Zika virus NS2B/NS3 protease inhibitor and its acyclic analogs.

Hammerschmidt SJ, Huber S, Braun NJ, Lander M, Steinmetzer T, Kersten C. Hammerschmidt SJ, et al. Arch Pharm (Weinheim). 2023 Apr;356(4):e2200518. doi: 10.1002/ardp.202200518. Epub 2022 Dec 8. Arch Pharm (Weinheim). 2023. PMID: 36480352

10

A low-cost 3D-printable differential scanning fluorometer for protein and RNA melting experiments.

Barthels F, Hammerschmidt SJ, Fischer TR, Zimmer C, Kallert E, Helm M, Kersten C, Schirmeister T. Barthels F, et al. Among authors: hammerschmidt sj. HardwareX. 2022 Jan 7;11:e00256. doi: 10.1016/j.ohx.2022.e00256. eCollection 2022 Apr. HardwareX. 2022. PMID: 35509940 Free PMC article.

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