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Discovery of Protease-Activated Receptor 4 (PAR4)-Tethered Ligand Antagonists Using Ultralarge Virtual Screening.
Smith ST, Cassada JB, Von Bredow L, Erreger K, Webb EM, Trombley TA, Kalbfleisch JJ, Bender BJ, Zagol-Ikapitte I, Kramlinger VM, Bouchard JL, Mitchell SG, Tretbar M, Shoichet BK, Lindsley CW, Meiler J, Hamm HE. Smith ST, et al. Among authors: hamm he. ACS Pharmacol Transl Sci. 2024 Mar 21;7(4):1086-1100. doi: 10.1021/acsptsci.3c00378. eCollection 2024 Apr 12. ACS Pharmacol Transl Sci. 2024. PMID: 38633591
Pepperberg plot: Modeling flash response saturation in retinal rods of mouse.
Caruso G, Klaus C, Hamm HE, Gurevich VV, Bisegna P, Andreucci D, DiBenedetto E, Makino CL. Caruso G, et al. Among authors: hamm he. Front Mol Neurosci. 2023 Jan 13;15:1054449. doi: 10.3389/fnmol.2022.1054449. eCollection 2022. Front Mol Neurosci. 2023. PMID: 36710929 Free PMC article.
Gβγ-SNAP25 exocytotic brake removal enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity.
Ceddia RP, Zurawski Z, Thompson Gray A, Adegboye F, McDonald-Boyer A, Shi F, Liu D, Maldonado J, Feng J, Li Y, Alford S, Ayala JE, McGuinness OP, Collins S, Hamm HE. Ceddia RP, et al. Among authors: hamm he. J Clin Invest. 2023 Oct 2;133(19):e160617. doi: 10.1172/JCI160617. J Clin Invest. 2023. PMID: 37561580 Free PMC article.
Discovery and Optimization of a Novel Series of Competitive and Central Nervous System-Penetrant Protease-Activated Receptor 4 (PAR4) Inhibitors.
Bertron JL, Duvernay MT, Mitchell SG, Smith ST, Maeng JG, Blobaum AL, Davis DC, Meiler J, Hamm HE, Lindsley CW. Bertron JL, et al. Among authors: hamm he. ACS Chem Neurosci. 2021 Dec 15;12(24):4524-4534. doi: 10.1021/acschemneuro.1c00557. Epub 2021 Dec 2. ACS Chem Neurosci. 2021. PMID: 34855359 Free PMC article.
Phototransduction in retinal cones: Analysis of parameter importance.
Klaus C, Caruso G, Gurevich VV, Hamm HE, Makino CL, DiBenedetto E. Klaus C, et al. Among authors: hamm he. PLoS One. 2021 Oct 28;16(10):e0258721. doi: 10.1371/journal.pone.0258721. eCollection 2021. PLoS One. 2021. PMID: 34710119 Free PMC article.
202 results