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Ribosomal biogenesis regulator DIMT1 controls β-cell protein synthesis, mitochondrial function, and insulin secretion.
Verma G, Bowen A, Gheibi S, Hamilton A, Muthukumar S, Cataldo LR, Asplund O, Esguerra J, Karagiannopoulos A, Lyons C, Cowan E, Bellodi C, Prasad R, Fex M, Mulder H. Verma G, et al. Among authors: hamilton a. J Biol Chem. 2022 Mar;298(3):101692. doi: 10.1016/j.jbc.2022.101692. Epub 2022 Feb 8. J Biol Chem. 2022. PMID: 35148993 Free PMC article.
Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes.
Adam J, Ramracheya R, Chibalina MV, Ternette N, Hamilton A, Tarasov AI, Zhang Q, Rebelato E, Rorsman NJG, Martín-Del-Río R, Lewis A, Özkan G, Do HW, Spégel P, Saitoh K, Kato K, Igarashi K, Kessler BM, Pugh CW, Tamarit-Rodriguez J, Mulder H, Clark A, Frizzell N, Soga T, Ashcroft FM, Silver A, Pollard PJ, Rorsman P. Adam J, et al. Among authors: hamilton a. Cell Rep. 2017 Sep 26;20(13):3135-3148. doi: 10.1016/j.celrep.2017.08.093. Cell Rep. 2017. PMID: 28954230 Free PMC article.
Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion.
Vishnu N, Hamilton A, Bagge A, Wernersson A, Cowan E, Barnard H, Sancak Y, Kamer KJ, Spégel P, Fex M, Tengholm A, Mootha VK, Nicholls DG, Mulder H. Vishnu N, et al. Among authors: hamilton a. Mol Metab. 2021 Sep;51:101239. doi: 10.1016/j.molmet.2021.101239. Epub 2021 Apr 28. Mol Metab. 2021. PMID: 33932586 Free PMC article.
RNA sequencing unravels novel L cell constituents and mechanisms of GLP-1 secretion in human gastric bypass-operated intestine.
Miskelly MG, Lindqvist A, Piccinin E, Hamilton A, Cowan E, Nergård BJ, Del Giudice R, Ngara M, Cataldo LR, Kryvokhyzha D, Volkov P, Engelking L, Artner I, Lagerstedt JO, Eliasson L, Ahlqvist E, Moschetta A, Hedenbro J, Wierup N. Miskelly MG, et al. Among authors: hamilton a. Diabetologia. 2024 Feb;67(2):356-370. doi: 10.1007/s00125-023-06046-8. Epub 2023 Nov 30. Diabetologia. 2024. PMID: 38032369 Free PMC article.
Genes with epigenetic alterations in human pancreatic islets impact mitochondrial function, insulin secretion, and type 2 diabetes.
Rönn T, Ofori JK, Perfilyev A, Hamilton A, Pircs K, Eichelmann F, Garcia-Calzon S, Karagiannopoulos A, Stenlund H, Wendt A, Volkov P, Schulze MB, Mulder H, Eliasson L, Ruhrmann S, Bacos K, Ling C. Rönn T, et al. Among authors: hamilton a. Nat Commun. 2023 Dec 12;14(1):8040. doi: 10.1038/s41467-023-43719-9. Nat Commun. 2023. PMID: 38086799 Free PMC article.
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion.
Vergari E, Knudsen JG, Ramracheya R, Salehi A, Zhang Q, Adam J, Asterholm IW, Benrick A, Briant LJB, Chibalina MV, Gribble FM, Hamilton A, Hastoy B, Reimann F, Rorsman NJG, Spiliotis II, Tarasov A, Wu Y, Ashcroft FM, Rorsman P. Vergari E, et al. Among authors: hamilton a. Nat Commun. 2019 Jan 11;10(1):139. doi: 10.1038/s41467-018-08193-8. Nat Commun. 2019. PMID: 30635569 Free PMC article.
Somatostatin secretion by Na+-dependent Ca2+-induced Ca2+ release in pancreatic delta-cells.
Vergari E, Denwood G, Salehi A, Zhang Q, Adam J, Alrifaiy A, Wernstedt Asterholm I, Benrick A, Chibalina MV, Eliasson L, Guida C, Hill TG, Hamilton A, Ramracheya R, Reimann F, Rorsman NJG, Spilliotis I, Tarasov AI, Walker JN, Rorsman P, Briant LJB. Vergari E, et al. Among authors: hamilton a. Nat Metab. 2020 Jan;2(1):32-40. doi: 10.1038/s42255-019-0158-0. Epub 2020 Jan 20. Nat Metab. 2020. PMID: 31993555 Free PMC article.
3,155 results