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Discovery of 1-{4-[1-(2,6-difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a potent, orally active, non-peptide antagonist of the human gonadotropin-releasing hormone receptor.
Miwa K, Hitaka T, Imada T, Sasaki S, Yoshimatsu M, Kusaka M, Tanaka A, Nakata D, Furuya S, Endo S, Hamamura K, Kitazaki T. Miwa K, et al. Among authors: hamamura k. J Med Chem. 2011 Jul 28;54(14):4998-5012. doi: 10.1021/jm200216q. Epub 2011 Jun 23. J Med Chem. 2011. PMID: 21657270
Regulation of Glycosylation in Bone Metabolism.
Hamamura K, Nagao M, Furukawa K. Hamamura K, et al. Int J Mol Sci. 2024 Mar 22;25(7):3568. doi: 10.3390/ijms25073568. Int J Mol Sci. 2024. PMID: 38612379 Free PMC article. Review.
Circadian rhythms in CYP2A5 expression underlie the time-dependent effect of tegafur on breast cancer.
Yoshida Y, Fukuda T, Tanihara T, Nishikawa N, Iwasa S, Adachi S, Zaitsu O, Terada Y, Tsukamoto R, Shimoshikiryo H, Fukuoka K, Tsurusaki F, Hamamura K, Oyama K, Tsuruta A, Koyanagi S, Matsunaga N, Ohdo S. Yoshida Y, et al. Among authors: hamamura k. Biochem Biophys Res Commun. 2024 May 14;708:149813. doi: 10.1016/j.bbrc.2024.149813. Epub 2024 Mar 20. Biochem Biophys Res Commun. 2024. PMID: 38522403
Inhibition of G protein-coupled receptor 68 using homoharringtonine attenuates chronic kidney disease-associated cardiac impairment.
Yoshida Y, Fukuoka K, Sakugawa M, Kurogi M, Hamamura K, Hamasaki K, Tsurusaki F, Sotono K, Nishi T, Fukuda T, Kumamoto T, Oyama K, Ogino T, Tsuruta A, Mayanagi K, Yamashita T, Fuchino H, Kawahara N, Yoshimatsu K, Kawakami H, Koyanagi S, Matsunaga N, Ohdo S. Yoshida Y, et al. Among authors: hamamura k. Transl Res. 2024 Jul;269:31-46. doi: 10.1016/j.trsl.2024.02.004. Epub 2024 Feb 23. Transl Res. 2024. PMID: 38401836
Prostaglandin F2α Affects the Cycle of Clock Gene Expression and Mouse Behavior.
Tsurudome Y, Yoshida Y, Hamamura K, Ogino T, Yasukochi S, Yasuo S, Iwamoto A, Yoshihara T, Inazumi T, Tsuchiya S, Takeo T, Nakagata N, Higuchi S, Sugimoto Y, Tsuruta A, Koyanagi S, Matsunaga N, Ohdo S. Tsurudome Y, et al. Among authors: hamamura k. Int J Mol Sci. 2024 Feb 2;25(3):1841. doi: 10.3390/ijms25031841. Int J Mol Sci. 2024. PMID: 38339119 Free PMC article.
161 results