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Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19.
Akamatsu M, Mikami N, Ohkura N, Kawakami R, Kitagawa Y, Sugimoto A, Hirota K, Nakamura N, Ujihara S, Kurosaki T, Hamaguchi H, Harada H, Xia G, Morita Y, Aramori I, Narumiya S, Sakaguchi S. Akamatsu M, et al. Among authors: hamaguchi h. Sci Immunol. 2019 Oct 25;4(40):eaaw2707. doi: 10.1126/sciimmunol.aaw2707. Sci Immunol. 2019. PMID: 31653719
PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment.
Thumkeo D, Punyawatthananukool S, Prasongtanakij S, Matsuura R, Arima K, Nie H, Yamamoto R, Aoyama N, Hamaguchi H, Sugahara S, Takeda S, Charoensawan V, Tanaka A, Sakaguchi S, Narumiya S. Thumkeo D, et al. Among authors: hamaguchi h. Cell Rep. 2022 Jun 7;39(10):110914. doi: 10.1016/j.celrep.2022.110914. Cell Rep. 2022. PMID: 35675777 Free article.
Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3.
Nakajima Y, Inoue T, Nakai K, Mukoyoshi K, Hamaguchi H, Hatanaka K, Sasaki H, Tanaka A, Takahashi F, Kunikawa S, Usuda H, Moritomo A, Higashi Y, Inami M, Shirakami S. Nakajima Y, et al. Among authors: hamaguchi h. Bioorg Med Chem. 2015 Aug 1;23(15):4871-4883. doi: 10.1016/j.bmc.2015.05.034. Epub 2015 May 27. Bioorg Med Chem. 2015. PMID: 26071372
Synthesis and evaluation of 1H-pyrrolo[2,3-b]pyridine derivatives as novel immunomodulators targeting Janus kinase 3.
Nakajima Y, Tojo T, Morita M, Hatanaka K, Shirakami S, Tanaka A, Sasaki H, Nakai K, Mukoyoshi K, Hamaguchi H, Takahashi F, Moritomo A, Higashi Y, Inoue T. Nakajima Y, et al. Among authors: hamaguchi h. Chem Pharm Bull (Tokyo). 2015;63(5):341-53. doi: 10.1248/cpb.c15-00036. Epub 2015 Mar 14. Chem Pharm Bull (Tokyo). 2015. PMID: 25786493 Free article.
Corrigendum to "Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3" [Bioorg. Med. Chem. 23 (2015) 4871-4883].
Nakajima Y, Inoue T, Nakai K, Mukoyoshi K, Hamaguchi H, Hatanaka K, Sasaki H, Tanaka A, Takahashi F, Kunikawa S, Usuda H, Moritomo A, Higashi Y, Inami M, Shirakami S. Nakajima Y, et al. Among authors: hamaguchi h. Bioorg Med Chem. 2016 Sep 15;24(18):4517. doi: 10.1016/j.bmc.2016.07.015. Epub 2016 Jul 15. Bioorg Med Chem. 2016. PMID: 27544046 No abstract available.
Corrigendum to "Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3" [Bioorg. Med. Chem. 23 (2015) 4871-4883].
Nakajima Y, Inoue T, Nakai K, Mukoyoshi K, Hamaguchi H, Hatanaka K, Sasaki H, Tanaka A, Takahashi F, Kunikawa S, Usuda H, Moritomo A, Higashi Y, Inami M, Shirakami S. Nakajima Y, et al. Among authors: hamaguchi h. Bioorg Med Chem. 2017 May 15;25(10):2813. doi: 10.1016/j.bmc.2017.03.043. Epub 2017 Mar 30. Bioorg Med Chem. 2017. PMID: 28366269 No abstract available.
490 results